Gene

mcm3

ID

ZDB-GENE-020419-4

Name

minichromosome maintenance complex component 3

Symbol

mcm3 Nomenclature History

Previous Names

MCM3z (1)
cb32 (1)
chunp6867
MCM3 minichromosome maintenance deficient 3
wu:fa26g03

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Enables chromatin binding activity. Acts upstream of or within retina development in camera-type eye. Predicted to be located in chromosome. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; blood; musculature system; nervous system; and testis. Orthologous to human MCM3 (minichromosome maintenance complex component 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb32 (4 images)
IMAGE:7162695 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mcm3 Human Ortholog

No data available

Associated With mcm3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018525	Mini-chromosome maintenance, conserved site
Domain	IPR001208	MCM domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR027925	MCM, N-terminal domain
Domain	IPR033762	MCM OB domain
Domain	IPR041562	MCM, AAA-lid domain
Family	IPR008046	DNA replication licensing factor Mcm3
Family	IPR031327	Mini-chromosome maintenance protein
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Additional Resources	Length	AAA+ ATPase domain	DNA replication licensing factor Mcm3	MCM, AAA-lid domain	MCM domain	MCM, N-terminal domain	MCM OB domain	Mini-chromosome maintenance, conserved site	Mini-chromosome maintenance protein	Nucleic acid-binding, OB-fold	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q5RIC5	InterPro	807

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	mcm3-201 (1) Ensembl	Ensembl		3,062 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-mcm3	polyclonal	mcm3	IgG	Rabbit	WB	Bethyl Laboratories, Inc.	3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations