Gene

dtl

ID
ZDB-GENE-020419-34
Name
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
Symbol
dtl Nomenclature History
Previous Names
  • cb151 (1)
  • chunp6871
  • denticleless homolog
  • wu:fb54b02 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Is predicted to contribute to ubiquitin-protein transferase activity. Involved in mitotic G2 DNA damage checkpoint and signal transduction involved in G2 DNA damage checkpoint. Predicted to localize to Cul4-RING E3 ubiquitin ligase complex; centrosome; and nucleus. Is expressed in several structures, including central nervous system; immature eye; mesoderm; optic primordium; and tail bud. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2001
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dtl Human Ortholog
No data available
Associated With dtl Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019775 WD40 repeat, conserved site
Domain IPR017986 WD40-repeat-containing domain
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR001680 WD40 repeat
Repeat IPR020472 G-protein beta WD-40 repeat
Domain Details Per Protein
Protein Length G-protein beta WD-40 repeat WD40 repeat WD40 repeat, conserved site WD40-repeat-containing domain WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q5RHI5 647
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations