Gene
mcm2
- ID
- ZDB-GENE-020419-24
- Name
- minichromosome maintenance complex component 2
- Symbol
- mcm2 Nomenclature History
- Previous Names
-
- cb737 (1)
- chunp6905
- MCM2 minichromosome maintenance deficient 2
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables chromatin binding activity. Acts upstream of or within regulation of cilium assembly; retina development in camera-type eye; and thymus development. Predicted to be located in nuclear chromosome. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in several structures, including hindbrain neural rod; midbrain neural rod; optic vesicle; paraxial mesoderm; and thymus. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb737 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 70 | Alliance | ?Deafness, autosomal dominant 70 | 616968 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018525 | Mini-chromosome maintenance, conserved site |
| Domain | IPR001208 | MCM domain |
| Domain | IPR027925 | MCM, N-terminal domain |
| Domain | IPR033762 | MCM OB domain |
| Domain | IPR041562 | MCM, AAA-lid domain |
| Family | IPR008045 | DNA replication licensing factor Mcm2 |
| Family | IPR031327 | Mini-chromosome maintenance protein |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA replication licensing factor Mcm2 | MCM, AAA-lid domain | MCM domain | MCM, N-terminal domain | MCM OB domain | Mini-chromosome maintenance, conserved site | Mini-chromosome maintenance protein | Nucleic acid-binding, OB-fold | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IF65 | InterPro | 889 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-mcm2 | polyclonal | IgG1 | Rabbit |
|
BD Biosciences
|
2 |
Plasmids
No data available