Gene
mcm2
- ID
- ZDB-GENE-020419-24
- Name
- minichromosome maintenance complex component 2
- Symbol
- mcm2 Nomenclature History
- Previous Names
-
- cb737 (1)
- chunp6905
- MCM2 minichromosome maintenance deficient 2
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables chromatin binding activity. Acts upstream of or within regulation of cilium assembly; retina development in camera-type eye; and thymus development. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in several structures, including hindbrain neural rod; midbrain neural rod; optic vesicle; paraxial mesoderm; and thymus. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb737 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 70 | Alliance | ?Deafness, autosomal dominant 70 | 616968 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018525 | Mini-chromosome maintenance, conserved site |
| Domain | IPR001208 | MCM domain |
| Domain | IPR027925 | MCM, N-terminal domain |
| Domain | IPR033762 | MCM OB domain |
| Domain | IPR041562 | MCM, AAA-lid domain |
| Family | IPR008045 | DNA replication licensing factor Mcm2 |
| Family | IPR031327 | Mini-chromosome maintenance protein |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | DNA replication licensing factor Mcm2 | MCM, AAA-lid domain | MCM domain | MCM, N-terminal domain | MCM OB domain | Mini-chromosome maintenance, conserved site | Mini-chromosome maintenance protein | Nucleic acid-binding, OB-fold | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IF65
|
889 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-mcm2 | polyclonal | IgG1 | Rabbit |
|
BD Biosciences
|
2 |
Plasmids
No data available