Gene
sf3b4
- ID
- ZDB-GENE-020419-22
- Name
- splicing factor 3b, subunit 4
- Symbol
- sf3b4 Nomenclature History
- Previous Names
-
- chunp6902
- fb36a04
- wu:fb36a04 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have RNA binding activity. Predicted to be involved in positive regulation of mRNA splicing, via spliceosome. Predicted to localize to U12-type spliceosomal complex and nucleolus. Human ortholog(s) of this gene implicated in Nager acrofacial dysostosis. Orthologous to human SF3B4 (splicing factor 3b subunit 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85842 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Nager acrofacial dysostosis | Alliance | Acrofacial dysostosis 1, Nager type | 154400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR034158 | SF3B4, RNA recognition motif 1 |
| Domain | IPR034159 | SF3B4, RNA recognition motif 2 |
| Family | IPR052084 | Spliceosome-associated SF3B4 subunit |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | SF3B4, RNA recognition motif 1 | SF3B4, RNA recognition motif 2 | Spliceosome-associated SF3B4 subunit |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NWB3
|
400 |
Interactions and Pathways
No data available
Plasmids
No data available