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ZIRC
ZFIN ID: ZDB-GENE-020419-11
Gene Name: ATPase H+ transporting V1 subunit E1b
Gene Symbol: atp6v1e1b    Nomenclature History

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Previous Names: atp6e, atp6v1e1, chunp6932, etID60363.4 (1), fj35f08, wu:fj35f08 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Exhibits potassium:proton exchanging ATPase activity. Involved in several processes, including caudal fin development; fin regeneration; and notochord cell vacuolation. Predicted to localize to the proton-transporting two-sector ATPase complex, catalytic domain. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIC. Is expressed in several structures, including digestive system; eye; gonad; heart; and unfertilized egg. Orthologous to several human genes including ATP6V1E1 (ATPase H+ transporting V1 subunit E1).
Genome Resources: Alliance (1),  Gene:192335 (1),  Ensembl(GRCz11):ENSDARG00000030694 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi577aTg Transgenic Insertion 5' UTR Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-atp6v1e1b N/A 1
    MO2-atp6v1e1b N/A 1
    DISEASE ASSOCIATED WITH atp6v1e1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive cutis laxa type IIC Alliance Cutis laxa, autosomal recessive, type IIC 617402
    DISEASE ASSOCIATED WITH atp6v1e1b VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002842 (1)
  • InterPro:IPR038495 (1)
  • Pfam:PF01991 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atp6v1e1b-201 (1)    Ensembl 1330
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atp6v1e1b No data available
    MARKER RELATIONSHIPS
    atp6v1e1b Contained in: [BAC] CH211-214J24 (1) (order this)
    atp6v1e1b Encodes: [EST] fj35f08 (1)
    [STS] chunp6932
    [cDNA] MGC:65808 (1) (order this), MGC:85648 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_173254 (1) 1269 bp
    Genomic GenBank:BX323558 (1) 160379 bp
    Select Tool
    Polypeptide UniProtKB:Q6NWK4 (1) 226 aa
    Sequence Clusters UniGene:80286 (1)
    Sequence Information (all 19)
    ORTHOLOGY for atp6v1e1b ( Chr: 4 )
    CITATIONS (38)