Gene

mkrn1

ID

ZDB-GENE-020213-1

Name

makorin, ring finger protein, 1

Symbol

mkrn1 Nomenclature History

Previous Names

fl25h08
wu:fl25h08 (1)
zgc:110403

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Is expressed in several structures, including brain; eye; gonad; integument; and liver. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110403 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mkrn1 Human Ortholog

No data available

Associated With mkrn1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR000571	Zinc finger, CCCH-type
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR031644	E3 ubiquitin-protein ligase makorin 1, C-terminal
Domain	IPR041367	E3 ligase, CCCH-type zinc finger
Family	IPR045072	MKRN-like
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036855	Zinc finger, CCCH-type superfamily

Domain Details Per Protein

Protein	Length	E3 ligase, CCCH-type zinc finger	E3 ubiquitin-protein ligase makorin 1, C-terminal	MKRN-like	Zinc finger, CCCH-type	Zinc finger, CCCH-type superfamily	Zinc finger, RING/FYVE/PHD-type	Zinc finger, RING-type	Zinc finger, RING-type, conserved site
UniProtKB:B2GQH3 InterPro	439
UniProtKB:Q4VBT5 InterPro	439

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	mkrn1-206 (1) Ensembl	Ensembl	702 nt	Select Tool ZFIN BLAST
mRNA	mkrn1-201 (1) Ensembl	Ensembl	2,383 nt	Select Tool ZFIN BLAST
mRNA	mkrn1-207 (1) Ensembl	Ensembl	710 nt	Select Tool ZFIN BLAST
ncRNA	mkrn1-003 (1) Ensembl	Ensembl	632 nt	Select Tool ZFIN BLAST
ncRNA	mkrn1-004 (1) Ensembl	Ensembl	814 nt	Select Tool ZFIN BLAST
ncRNA	mkrn1-005 (1) Ensembl	Ensembl	295 nt	Select Tool ZFIN BLAST
ncRNA	mkrn1-006 (1) Ensembl	Ensembl	501 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations