Gene

gria2b

ID

ZDB-GENE-020125-4

Name

glutamate receptor, ionotropic, AMPA 2b

Symbol

gria2b Nomenclature History

Previous Names

glur2b (1)
gria2.2
zfGRIA2[b] (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have AMPA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to localize to AMPA glutamate receptor complex; dendritic spine; and postsynaptic density membrane. Is expressed in central nervous system; retinal neural layer; and sensory neurons. Orthologous to human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu643 (1 image)
eu924 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gria2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with language impairment and behavioral abnormalities	618917

Associated With gria2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001320	Ionotropic glutamate receptor, C-terminal
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR019594	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family	IPR001508	Ionotropic glutamate receptor, metazoa
Family	IPR015683	Ionotropic glutamate receptor
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I

Domain Details Per Protein

Protein	Length	Ionotropic glutamate receptor	Ionotropic glutamate receptor, C-terminal	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain	Ionotropic glutamate receptor, metazoa	Periplasmic binding protein-like I	Receptor, ligand binding region
UniProtKB:Q71E62 InterPro	879
UniProtKB:A0A286YAM5 InterPro	897
UniProtKB:A0A140LG34 InterPro	879
UniProtKB:F1QKT1 InterPro	897

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gria2b-201 (1) Ensembl	Ensembl	4,505 nt	Select Tool
mRNA	gria2b-202 (1) Ensembl	Ensembl	3,011 nt	Select Tool
mRNA	gria2b-205 (1) Ensembl	Ensembl	2,724 nt	Select Tool
mRNA	gria2b-206 (1) Ensembl	Ensembl	446 nt	Select Tool
mRNA	gria2b-207 (1) Ensembl	Ensembl	4,618 nt	Select Tool ZFIN BLAST
ncRNA	gria2b-003 (1) Ensembl	Ensembl	671 nt	Select Tool
ncRNA	gria2b-004 (1) Ensembl	Ensembl	535 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations