Gene

meis2a

ID
ZDB-GENE-020122-2
Name
Meis homeobox 2a
Symbol
meis2a Nomenclature History
Previous Names
  • meis2.2
  • fa26d08
  • wu:fa26d08 (1)
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic viscerocranium morphogenesis. Predicted to localize to nucleus. Is expressed in several structures, including anterior neural keel; hindbrain neural keel; nervous system; neural plate; and neural rod. Human ortholog(s) of this gene implicated in cleft palate, cardiac defects, and intellectual disabillity. Orthologous to human MEIS2 (Meis homeobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Melvin et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With meis2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cleft palate, cardiac defects, and intellectual disabillity Alliance Cleft palate, cardiac defects, and mental retardation 600987
Associated With meis2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001356 Homeobox domain
Domain IPR008422 Homeobox KN domain
Domain IPR032453 Homeobox protein PKNOX/Meis, N-terminal
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations