Gene

dmbx1a

ID
ZDB-GENE-020117-1
Name
diencephalon/mesencephalon homeobox 1a
Symbol
dmbx1a Nomenclature History
Previous Names
  • dmbx1 (1)
  • mbx (1)
  • otx3
  • zMbx1 (1)
  • etID309750.1 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in brain development; eye development; and negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including midbrain development; regulation of neural retina development; and retina development in camera-type eye. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural keel; anterior neural rod; immature eye; nervous system; and presumptive diencephalon. Orthologous to human DMBX1 (diencephalon/mesencephalon homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
24 figures from 18 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Wong et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dmbx1a Human Ortholog
No data available
Associated With dmbx1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003654 OAR domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily OAR domain
UniProtKB:A4IG24 383
UniProtKB:Q8JI10 388
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations