ZFIN ID: ZDB-GENE-020104-1
Gene Name: HNF1 homeobox Ba
Gene Symbol: hnf1ba    Nomenclature History

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Previous Names: hnf1b (1), hob, vhnf1 (2), chunp6877, mst, tcf2 (1), transcription factor 2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in several processes, including animal organ development; endoderm formation; and glucose homeostasis. Predicted to localize to nucleus. Is expressed in several structures, including digestive system; heart; neural plate; posterior neural keel; and pronephros. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B).
Genome Resources: Alliance (1),  Gene:792391 (1),  Ensembl(GRCz11):ENSDARG00000006615 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi548Tg Transgenic Insertion Intron 6 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi1843Tg Transgenic Insertion Exon 3 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi2169Tg Transgenic Insertion Exon 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la550 Unknown Unknown Unknown ENU
    la1146 Unknown Unknown Unknown ENU
    la019161Tg Transgenic Insertion Unknown Unknown DNA
    s430 Point Mutation Unknown Missense ENU
    s917 Point Mutation Unknown Premature Stop ENU
    sa10100 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • wi408 Unknown Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-hnf1ba N/A 3
    MO2-hnf1ba N/A 1
    MO3-hnf1ba N/A 2
    MO4-hnf1ba N/A 1
    MO5-hnf1ba N/A 1
    DISEASE ASSOCIATED WITH hnf1ba HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    maturity-onset diabetes of the young type 5 Alliance Renal cysts and diabetes syndrome 137920
    nonpapillary renal cell carcinoma Alliance {Renal cell carcinoma} 144700
    type 2 diabetes mellitus Alliance Diabetes mellitus, noninsulin-dependent 125853
    DISEASE ASSOCIATED WITH hnf1ba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endoderm formation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 35)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hnf1ba-201 (1)    Ensembl 4167
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hnf1ba No data available
    MARKER RELATIONSHIPS
    hnf1ba Contained in: [BAC] DKEYP-118E10 (1)
    hnf1ba Encodes: [EST] af244140 (1)
    [cDNA] MGC:158167 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131880 (1) 4167 nt
    Genomic GenBank:BX511308 (1) 123109 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IR44 (1) 559 aa
    Sequence Information (all 28)
    ORTHOLOGY for hnf1ba ( Chr: 15 )
    CITATIONS (91)