Gene

hnf1ba

ID
ZDB-GENE-020104-1
Name
HNF1 homeobox Ba
Symbol
hnf1ba Nomenclature History
Previous Names
  • hnf1b (1)
  • hob
  • vhnf1 (2)
  • chunp6877
  • mst
  • tcf2 (1)
  • transcription factor 2
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity; RNA polymerase II regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in several processes, including animal organ development; endoderm formation; and glucose homeostasis. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Is expressed in several structures, including digestive system; heart; neural plate; posterior neural keel; and pronephros. Orthologous to human HNF1B (HNF1 homeobox B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
47 figures from 32 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
40 figures from 19 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hnf1ba Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
maturity-onset diabetes of the young type 5 Alliance Renal cysts and diabetes syndrome 137920
nonpapillary renal cell carcinoma Alliance {Renal cell carcinoma} 144700
type 2 diabetes mellitus Alliance Type 2 diabetes mellitus 125853
Associated With hnf1ba Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001356 Homeodomain
Domain IPR006897 Hepatocyte nuclear factor 1, beta isoform, C-terminal
Domain IPR006899 Hepatocyte nuclear factor 1, N-terminal
Domain IPR044866 HNF-1, dimerization domain
Domain IPR044869 HNF-1, POU-specific (POUs) atypical domain
Family IPR039066 Hepatocyte nuclear factor 1
Homologous_superfamily IPR009057 Homedomain-like superfamily
Homologous_superfamily IPR010982 Lambda repressor-like, DNA-binding domain superfamily
Homologous_superfamily IPR023219 Hepatocyte nuclear factor 1, N-terminal domain superfamily
Domain Details Per Protein
Protein Length Hepatocyte nuclear factor 1 Hepatocyte nuclear factor 1, beta isoform, C-terminal Hepatocyte nuclear factor 1, N-terminal Hepatocyte nuclear factor 1, N-terminal domain superfamily HNF-1, dimerization domain HNF-1, POU-specific (POUs) atypical domain Homedomain-like superfamily Homeodomain Lambda repressor-like, DNA-binding domain superfamily
UniProtKB:A1L1N5 559
UniProtKB:A0A8M9QC63 456
UniProtKB:A0A0R4IR44 559
UniProtKB:A0A8M9Q0L2 586
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA hnf1ba-201 (1) Ensembl 4,167 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations