Gene
hnf1ba
- ID
- ZDB-GENE-020104-1
- Name
- HNF1 homeobox Ba
- Symbol
- hnf1ba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in hindbrain development. Acts upstream of or within several processes, including embryonic organ development; hindbrain development; and liver development. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; heart; neural plate; posterior neural keel; and pronephros. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 40 figures from 19 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi548Tg | Transgenic insertion | Intron 6 | Unknown | DNA | |
| hi1843Tg | Transgenic insertion | Exon 3 | Unknown | DNA | |
| hi2169Tg | Transgenic insertion | Exon 1 | Unknown | DNA | |
| ihb864 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| ihb865 | Allele with one delins | Exon 2 | Unknown | not specified | |
| la550 | unknown | Unknown | Unknown | ENU | |
| la1146 | unknown | Unknown | Unknown | ENU | |
| la019161Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| s430 | Allele with one point mutation | Unknown | Missense | ENU | |
| s917 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| maturity-onset diabetes of the young type 5 | Alliance | Renal cysts and diabetes syndrome | 137920 |
| nonpapillary renal cell carcinoma | Alliance | {Renal cell carcinoma} | 144700 |
| type 2 diabetes mellitus | Alliance | Type 2 diabetes mellitus | 125853 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001356 | Homeodomain |
| Domain | IPR006897 | Hepatocyte nuclear factor 1, beta isoform, C-terminal |
| Domain | IPR006899 | Hepatocyte nuclear factor 1, N-terminal |
| Domain | IPR044866 | HNF-1, dimerization domain |
| Domain | IPR044869 | HNF-1, POU-specific (POUs) atypical domain |
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Domain Details Per Protein
| Protein | Length | Hepatocyte nuclear factor 1 | Hepatocyte nuclear factor 1, beta isoform, C-terminal | Hepatocyte nuclear factor 1, N-terminal | Hepatocyte nuclear factor 1, N-terminal domain superfamily | HNF-1, dimerization domain | HNF-1, POU-specific (POUs) atypical domain | Homedomain-like superfamily | Homeodomain | Lambda repressor-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A1L1N5
|
559 | |||||||||
|
UniProtKB:A0A8M9QC63
|
456 | |||||||||
|
UniProtKB:A0A0R4IR44
|
559 | |||||||||
|
UniProtKB:A0A8M9Q0L2
|
586 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hnf1ba-201
(1)
|
Ensembl | 4,167 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(hnf1ba:GFP) |
|
| 1 | Zhao et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-118E10 | ZFIN Curated Data | |
| Encodes | EST | af244140 | Gong et al., 2004 | |
| Encodes | cDNA | MGC:158167 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131880 (1) | 4167 nt | ||
| Genomic | GenBank:BX511308 (1) | 123109 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q0L2 (1) | 586 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Mi, J., Liu, K.C., Andersson, O. (2023) Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish. Science advances. 9:eadf5142
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Qiu, Y., Fung, L., Schilling, T.F., Nie, Q. (2021) Multiple morphogens and rapid elongation promote segmental patterning during development. PLoS Computational Biology. 17:e1009077
- Zhao, C., Lancman, J.J., Yang, Y., Gates, K.P., Cao, D., Barske, L., Matalonga, J., Pan, X., He, J., Graves, A., Huisken, J., Chen, C., Dong, P.D.S. (2021) Intrahepatic cholangiocyte regeneration from an Fgf-dependent extrahepatic progenitor niche in a zebrafish model of Alagille Syndrome. Hepatology (Baltimore, Md.). 75(3):567-583
- Chambers, B.E., Gerlach, G.F., Clark, E.G., Chen, K.H., Levesque, A.E., Leshchiner, I., Goessling, W., Wingert, R.A. (2019) Tfap2a is a novel gatekeeper of nephron differentiation during kidney development. Development (Cambridge, England). 146(13):
- Sander, V., Salleh, L., Naylor, R.W., Schierding, W., Sontam, D.M., O'Sullivan, J.M., Davidson, A.J. (2019) Transcriptional profiling of the zebrafish proximal tubule. American journal of physiology. Renal physiology. 317(2):F478-F488
- Ghosh, P., Maurer, J.M., Sagerström, C.G. (2018) Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Neural Development. 13:13
- Naylor, R.W., Chang, H.G., Qubisi, S., Davidson, A.J. (2018) A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusion. eLIFE. 7:
- Pinto, R.A., Almeida-Santos, J., Lourenço, R., Saúde, L. (2018) Identification of Dmrt2a downstream genes during zebrafish early development using a timely controlled approach. BMC Developmental Biology. 18:14
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