ZFIN Gene: vim

ZFIN ID: ZDB-GENE-011212-3

ZFIN ID: ZDB-GENE-011212-3

Gene Name:

vimentin

Gene Symbol:

vim Nomenclature History

Previous Name:

cb28 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 24 Mapping Details/Browsers

Description:

Involved in wound healing. Predicted to localize to intermediate filament. Is expressed in several structures, including axis; integument; midbrain neural keel; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Behcet's disease; atherosclerosis; autoimmune hypersensitivity disease (multiple); cataract 30; and rheumatoid arthritis. Orthologous to human VIM (vimentin).

Genome Resources:

Alliance (1), Gene:140599 (1), Ensembl(GRCz11):ENSDARG00000010008 (2)

GENE EXPRESSION
All Expression Data:	17 figures from 8 publications
Directly Submitted Expression Data:	6 figures (16 images) from Thisse et al., 2001 [cb28]
Wild-type Stages, Structures:	Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
	amacrine cell axis brain bulbus arteriosus cerebellum cranial ganglion cranial nerve II cranial nerve X dermis diencephalon eye forebrain glioblast hindbrain integument intestine lateral line ganglion lens lens epithelium midbrain midbrain hindbrain boundary midbrain neural keel Muller cell neural plate neural tube neuron primary neuron retinal bipolar neuron retinal cone cell retinal ganglion cell layer retinal inner plexiform layer retinal outer plexiform layer retinal pigmented epithelium spinal cord glial cell spinal cord spinal cord neural tube trigeminal ganglion unspecified whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-vim		1
MO1-vim	N/A	1
MO2-vim	N/A	1

PHENOTYPE

Data:	2 figures from LeBert et al., 2018
Observed in:	fin regeneration regenerating fin wound healing

DISEASE ASSOCIATED WITH vim HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cataract 30	Alliance	Cataract 30, pulverulent	116300

DISEASE ASSOCIATED WITH vim VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	wound healing (more)
Cellular Component	intermediate filament (more)

GO Terms (all 2)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	vim-201 (1)	1861	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Source	Publications
Ab1-vim	monoclonal	IgG1	Mouse	IHC, WB	Sigma-Aldrich Millipore Dako North America, Inc. Abcam plc Novus Biologicals, LLC Vector Laboratories	10

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM vim

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(-2vim:EGFP)	vim	EGFP	Danio rerio	1	3

MARKER RELATIONSHIPS

vim Contained in:	[BAC] CH73-48E2 (1), CH211-266I10 (1)
vim Encodes:	[EST] cb28 (1) (order this) [cDNA] MGC:63857 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131872 (1)	1824 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU207275 (1)	165971 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1QAM8 (1)	455 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 17)

ORTHOLOGY for vim ( Chr: 24 )

CITATIONS (51)

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