ZFIN ID: ZDB-GENE-011210-2
Gene Name: X-box binding protein 1
Gene Symbol: xbp1    Nomenclature History

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Previous Names: cb918 (1), id:ibd1195, trebf (1), wu:fb02h05 (1), wu:fb63f10 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in gland development; hatching; and transcription by RNA polymerase II. Predicted to localize to integral component of endoplasmic reticulum membrane and nucleus. Is expressed in several structures, including axial mesoderm; axis; digestive system; ectoderm; and germ ring. Orthologous to human XBP1 (X-box binding protein 1).
Genome Resources: Alliance (1),  Gene:140614 (1),  Ensembl(GRCz11):ENSDARG00000035622 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024815Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40380 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-xbp1 N/A 2
    MO2-xbp1 N/A 1
    DISEASE ASSOCIATED WITH xbp1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Major affective disorder-7, susceptibility to} 612371
    DISEASE ASSOCIATED WITH xbp1 VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript xbp1-202 (1)    Ensembl 2135
    mRNA xbp1-203 (1)    Ensembl 1728
    ncRNA xbp1-003 (1)    Ensembl 813
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM xbp1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(krt4:xbp1,mCherry) krt4 mCherryxbp1 Danio rerio 1 2
    Tg(lyz:xbp1,EGFP) lyz EGFPxbp1 Danio rerio 1 2
    Tg(Xla.Eef1a1:xbp1-MYC-EGFP) EGFPMYCxbp1 Danio rerioXenopus laevis 3 3
    MARKER RELATIONSHIPS
    xbp1 Contained in: [BAC] CH211-201F12, DKEY-119P2 (1) (order this)
    xbp1 Encodes: [EST] cb918 (1), fb02h05 (1), ibd1195
    [cDNA] MGC:55240 (1), MGC:55241 (1), MGC:76840 (1), MGC:173917 (1), MGC:191954 (1)
    xbp1 Is Hybridized by: [EST] fb63f10
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131874 (1) 1769 nt
    Genomic GenBank:BX640473 193735 nt
    Select Tool
    Polypeptide UniProtKB:A7MCI6 (1) 383 aa
    Sequence Information (all 53)
    ORTHOLOGY for xbp1 ( Chr: 5 )
    CITATIONS (96)