Gene
xbp1
- ID
- ZDB-GENE-011210-2
- Name
- X-box binding protein 1
- Symbol
- xbp1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within several processes, including hatching; hatching gland development; and transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including axial mesoderm; digestive system; ectoderm; eye; and germ ring. Orthologous to human XBP1 (X-box binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 72 figures from 47 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55240 (23 images)
- cb918 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024815Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nju222 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa40380 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-xbp1 | Angueyra et al., 2023 | |
| CRISPR2-xbp1 | Angueyra et al., 2023 | |
| CRISPR3-xbp1 | Angueyra et al., 2023 | |
| CRISPR4-xbp1 | Yang et al., 2024 | |
| CRISPR5-xbp1 | Yang et al., 2024 | |
| MO1-xbp1 | N/A | (2) |
| MO2-xbp1 | N/A | Bennett et al., 2007 |
| MO3-xbp1 | N/A | Schürch et al., 2020 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Major affective disorder-7, susceptibility to} | 612371 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic-leucine zipper domain | Basic-leucine zipper domain superfamily | Endoplasmic Reticulum Stress-Regulated Transcription Factor |
|---|---|---|---|---|---|
| UniProtKB:Q90X27 | InterPro | 263 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(krt4:xbp1,mCherry) |
|
| 1 | (2) | |
| Tg(lyz:xbp1,EGFP) |
|
| 1 | (2) | |
| Tg(Xla.Eef1a1:xbp1-MYC-EGFP) |
| 3 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-201F12 | ||
| Contained in | BAC | DKEY-119P2 | ZFIN Curated Data | |
| Encodes | EST | cb918 | Thisse et al., 2001 | |
| Encodes | EST | fb02h05 | ZFIN Curated Data | |
| Encodes | EST | ibd1195 | ||
| Encodes | cDNA | MGC:55240 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55241 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76840 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173917 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191954 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131874 (1) | 1769 nt | ||
| Genomic | GenBank:BX640473 | 193735 nt | ||
| Polypeptide | UniProtKB:Q90X27 (1) | 263 aa |
- Ma, J., Chen, Y., Song, J., Ruan, Q., Li, L., Luo, L. (2025) Establishment and application of a zebrafish model of Werner syndrome identifies sapanisertib as a potential antiaging drug. Proceedings of the National Academy of Sciences of the United States of America. 122:e2413719122e2413719122
- Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Matheny-Rabun, C., Mokashi, S.S., Radenkovic, S., Wiggins, K., Dukes-Rimsky, L., Angel, P., Ghesquiere, B., Kozicz, T., Steet, R., Morava, E., Flanagan-Steet, H. (2024) O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder. Cell Reports. 43:114976114976
- Yang, Y., Zhang, X., Zhao, Q., Zhang, J., Lou, X. (2024) Compromised COPII vesicle trafficking leads to glycogenic hepatopathy in zebrafish. Disease models & mechanisms. 17(9):
- Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:
- Huttner, I.G., Santiago, C.F., Jacoby, A., Cheng, D., Trivedi, G., Cull, S., Cvetkovska, J., Chand, R., Berger, J., Currie, P.D., Smith, K.A., Fatkin, D. (2023) Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish. Journal of cardiovascular development and disease. 10(10):
- Mansur, A., Joseph, R., Kim, E., Jean-Beltran, P.M., Udeshi, N.D., Pearce, C., Jiang, H., Iwase, R., Milev, M.P., Almousa, H.A., McNamara, E., Widrick, J., Perez, C., Ravenscroft, G., Sacher, M., Cole, P.A., Carr, S.A., Gupta, V.A. (2023) Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset. eLIFE. 12:
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Zhu, Y., Hu, J., Zeng, S., Gao, M., Guo, S., Wang, M., Hong, Y., Zhao, G. (2023) L-selenomethionine affects liver development and glucolipid metabolism by inhibiting autophagy in zebrafish embryos. Ecotoxicology and environmental safety. 252:114589114589
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