Gene
gucy2d
- ID
- ZDB-GENE-011128-9
- Name
- guanylate cyclase 2D, retinal
- Symbol
- gucy2d Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to act upstream of or within several processes, including cyclic nucleotide biosynthetic process; protein phosphorylation; and visual perception. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Is expressed in head. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to human GUCY2D (guanylate cyclase 2D, retinal).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-gucy2d | N/A | Iribarne et al., 2017 |
| MO2-gucy2d | N/A | Iribarne et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| choroidal sclerosis | Alliance | ?Choroidal dystrophy, central areolar 1 | 215500 |
| cone-rod dystrophy 6 | Alliance | Cone-rod dystrophy 6 | 601777 |
| Leber congenital amaurosis 1 | Alliance | Leber congenital amaurosis 1 | 204000 |
| Night blindness, congenital stationary, type 1I | 618555 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018297 | Adenylyl cyclase class-4/guanylyl cyclase, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001054 | Adenylyl cyclase class-3/4/guanylyl cyclase |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001828 | Receptor, ligand binding region |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Adenylyl cyclase class-3/4/guanylyl cyclase | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | Cyclic nucleotide synthase | Haem NO binding associated | Nucleotide cyclase | Periplasmic binding protein-like I | Protein kinase domain | Protein kinase-like domain superfamily | Receptor, ligand binding region | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A5PLH7 | InterPro | 128 | ||||||||||
| UniProtKB:A0A8M2BCH5 | InterPro | 1141 | ||||||||||
| UniProtKB:F1QSL9 | InterPro | 1137 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gucy2d-201
(1)
|
Ensembl | 3,892 nt | ||
| mRNA |
gucy2d-202
(1)
|
Ensembl | 4,522 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-284E13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131866 (1) | 3892 nt | ||
| Genomic | GenBank:BX294181 (1) | 171388 nt | ||
| Polypeptide | UniProtKB:A0A8M2BCH5 (1) | 1141 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | GUCY2D | 17 | Amino acid sequence comparison (1) |
- Pillay, S., Takahashi, H., Carninci, P., Kanhere, A. (2021) Antisense RNAs during early vertebrate development are divided in groups with distinct features. Genome research. 31(6):995-1010
- Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
- Iribarne, M., Nishiwaki, Y., Nakamura, S., Araragi, M., Oguri, E., Masai, I. (2017) Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Scientific Reports. 7:45962
- Saraiva, L.R., Ahuja, G., Ivandic, I., Syed, A.S., Marioni, J.C., Korsching, S.I., Logan, D.W. (2015) Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Scientific Reports. 5:11487
- Tsai, H.Y., Hamilton, A., Tinch, A.E., Guy, D.R., Gharbi, K., Stear, M.J., Matika, O., Bishop, S.C., Houston, R.D. (2015) Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. BMC Genomics. 16:969
- Fries, R., Scholten, A., Säftel, W., and Koch, K.W. (2013) Zebrafish guanylate cyclase type 3 signaling in cone photoreceptors. PLoS One. 8(8):e69656
- Rätscho, N., Scholten, A., and Koch, K.W. (2009) Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina. Biochimica et biophysica acta. Molecular cell research. 1793(6):1110-1114
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
- Muto, A., Orger, M.B., Wehman, A.M., Smear, M.C., Kay, J.N., Page-McCaw, P.S., Gahtan, E., Xiao, T., Nevin, L.M., Gosse, N.J., Staub, W., Finger-Baier, K., Baier, H. (2005) Forward Genetic Analysis of Visual Behavior in Zebrafish. PLoS Genetics. 1(5):e66
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