Gene

sfrp5

ID
ZDB-GENE-011108-2
Name
secreted frizzled-related protein 5
Symbol
sfrp5 Nomenclature History
Previous Names
  • sfrp1 (1)
  • zgc:101849
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable Wnt-protein binding activity. Acts upstream of with a negative effect on canonical Wnt signaling pathway and non-canonical Wnt signaling pathway. Acts upstream of or within animal organ development; endodermal digestive tract morphogenesis; and regulation of signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including anterior neural keel; anterior neural rod; gut; immature eye; and nervous system. Orthologous to human SFRP5 (secreted frizzled related protein 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Stuckenholz et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sfrp5 Human Ortholog
No data available
Associated With sfrp5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001134 Netrin domain
Domain IPR018933 Netrin module, non-TIMP type
Domain IPR020067 Frizzled domain
Domain IPR041761 SFRP5, cysteine-rich domain
Family IPR015526 Frizzled/secreted frizzled-related protein
Family IPR034860 Secreted frizzled-related protein 5
Homologous_superfamily IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily IPR036790 Frizzled cysteine-rich domain superfamily
Domain Details Per Protein
Protein Length Frizzled cysteine-rich domain superfamily Frizzled domain Frizzled/secreted frizzled-related protein Netrin domain Netrin module, non-TIMP type Secreted frizzled-related protein 5 SFRP5, cysteine-rich domain Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:F1QJG6 310
UniProtKB:Q90ZG8 115
UniProtKB:Q6YNR8 310
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations