Gene

prkci

ID
ZDB-GENE-011105-1
Name
protein kinase C, iota
Symbol
prkci Nomenclature History
Previous Names
  • aPKC[l] (1)
  • has (1)
  • heart and soul
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have phospholipid binding activity and protein serine/threonine kinase activity. Involved in several processes, including animal organ development; digestive tract development; and morphogenesis of an epithelium. Localizes to intrinsic component of plasma membrane and zonula adherens. Is expressed in several structures, including blastoderm; common cardinal vein; eye; posterior lateral line primordium; and pronephric duct. Orthologous to human PRKCI (protein kinase C iota).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
39 figures from 20 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prkci Human Ortholog
No data available
Associated With prkci Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000270 PB1 domain
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR017892 Protein kinase, C-terminal
Domain IPR020454 Diacylglycerol/phorbol-ester binding
Domain IPR034661 Atypical protein kinase C iota type, catalytic domain
Domain IPR034877 Protein kinase C, PB1 domain
Family IPR012233 Protein kinase C
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal Atypical protein kinase C iota type, catalytic domain Diacylglycerol/phorbol-ester binding PB1 domain Protein kinase, ATP binding site Protein kinase C Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Protein kinase C, PB1 domain Protein kinase, C-terminal Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q6DI53 588
UniProtKB:Q90XF2 588
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-prkcz polyclonal IgG Rabbit
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
86
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations