Gene
ngb
- ID
- ZDB-GENE-011102-1
- Name
- neuroglobin
- Symbol
- ngb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables nitrite reductase activity and oxygen binding activity. Acts upstream of or within response to hypoxia. Predicted to be located in cytosol and mitochondrial matrix. Is expressed in blood; brain; and eye. Orthologous to human NGB (neuroglobin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| icm46 | Allele with one deletion | Exon 1 | Unknown | not specified |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Globin | Globin-like Oxygen Transporters | Globin-like superfamily | Globin/Protoglobin |
|---|---|---|---|---|---|---|
| UniProtKB:Q90YJ2 | InterPro | 159 | ||||
| UniProtKB:A0A8M9P002 | InterPro | 159 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-202H12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-233N24 | Fuchs et al., 2004 | |
| Encodes | cDNA | MGC:73028 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131853 (1) | 2596 nt | ||
| Genomic | GenBank:AL953899 (1) | 169796 nt | ||
| Polypeptide | UniProtKB:A0A8M9P002 (1) | 159 aa |
- Gao, S.Q., Yuan, H., Yang, X.Z., Xiang, H.F., Tan, X., Wen, G.B., Lin, Y.W. (2022) Improving the cell-membrane-penetrating activity of globins by introducing positive charges on protein surface: A case study of sperm whale myoglobin. Biochemical and Biophysical Research Communications. 598:26-31
- Kim, S.H., Yang, D., Bae, Y.A. (2021) Hypoxic and nitrosative stress conditions modulate expression of myoglobin genes in a carcinogenic hepatobiliary trematode, Clonorchis sinensis. PLoS neglected tropical diseases. 15:e0009811
- Lee, Y., Lee, S., Park, J.W., Hwang, J.S., Kim, S.M., Lyoo, I.K., Lee, C.J., Han, I.O. (2018) Hypoxia-Induced Neuroinflammation and Learning-Memory Impairments in Adult Zebrafish Are Suppressed by Glucosamine. Molecular neurobiology. 55(11):8738-8753
- Sugitani, K., Koriyama, Y., Sera, M., Arai, K., Ogai, K., Wakasugi, K. (2017) A novel function of neuroglobin for neuroregeneration in mice after optic nerve injury. Biochemical and Biophysical Research Communications. 493:1254-1259
- Takahashi, N., Onozuka, W., Watanabe, S., Wakasugi, K. (2017) Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth. FEBS Open Bio. 7:1338-1349
- Corti, P., Ieraci, M., Tejero, J. (2016) Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins. Nitric oxide : biology and chemistry. 53:22-34
- Corti, P., Xue, J., Tejero, J., Wajih, N., Sun, M., Stolz, D.B., Tsang, M., Kim-Shapiro, D.B., Gladwin, M.T. (2016) Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells. Proceedings of the National Academy of Sciences of the United States of America. 113:8538-43
- Kamioka, Y., Fujikawa, C., Ogai, K., Sugitani, K., Watanabe, S., Kato, S., and Wakasugi, K. (2013) Functional characterization of fish neuroglobin: Zebrafish neuroglobin is highly expressed in amacrine cells after optic nerve injury and can translocate into ZF4 cells. Biochimica et biophysica acta. Proteins and proteomics. 1834(9):1779-88
- Tiedke, J., Cubuk, C., and Burmester, T. (2013) Environmental acidification triggers oxidative stress and enhances globin expression in zebrafish gills. Biochemical and Biophysical Research Communications. 441(3):624-9
- Blank, M., and Burmester, T. (2012) Widespread occurrence of N-terminal acylation in animal globins and possible origin of respiratory globins from a membrane-bound ancestor. Mol. Biol. Evol.. 29(11):3553-3561
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