Gene
ncam2
- ID
- ZDB-GENE-010822-1
- Name
- neural cell adhesion molecule 2
- Symbol
- ncam2 Nomenclature History
- Previous Names
-
- zOCAM (1)
- sb:eu836
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Acts upstream of or within response to hypoxia. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in brain; sensory system; and swim bladder. Orthologous to human NCAM2 (neural cell adhesion molecule 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu836 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa18956 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31734 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34694 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38754 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Neural and epithelial cell adhesion domain-containing protein | Neural cell adhesion |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BFW0
|
726 | ||||||||||
|
UniProtKB:A0A8M2BF98
|
794 | ||||||||||
|
UniProtKB:Q90YM0
|
795 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-210P17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-205J8 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-257L1 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-75A3 | ZFIN Curated Data | |
| Encodes | EST | eu836 | Thisse et al., 2005 | |
| Encodes | cDNA | cssl:d827 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:193942 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131830 (1) | 2894 nt | ||
| Genomic | GenBank:CR759897 (2) | 196922 nt | ||
| Polypeptide | UniProtKB:Q90YM0 (1) | 795 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Manchenkov, T., Pasillas, M.P., Haddad, G.G., Imam, F.B. (2015) Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. G3 (Bethesda). 5(6):1107-16
- Staudt, N., Müller-Sienerth, N., Fane-Dremucheva, A., Yusaf, S.P., Millrine, D., Wright, G.J. (2015) A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining. Biochemical and Biophysical Research Communications. 456(1):527-33
- Langhauser, M., Ustinova, J., Rivera-Milla, E., Ivannikov, D., Seidl, C., Slomka, C., Finne, J., Yoshihara, Y., Bastmeyer, M., and Bentrop, J. (2012) Ncam1a and Ncam1b: Two carriers of polysialic acid with different functions in the developing zebrafish nervous system. Glycobiology. 22(2):196-209
- Brown, K.E., Keller, P.J., Ramialison, M., Rembold, M., Stelzer, E.H., Loosli, F., and Wittbrodt, J. (2010) Nlcam modulates midline convergence during anterior neural plate morphogenesis. Developmental Biology. 339(1):14-25
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Mizuno, T., Kawasaki, M., Nakahira, M., Kagamiyama, H., Kikuchi, Y., Okamoto, H., Mori, K., and Yoshihara, Y. (2001) Molecular diversity in zebrafish NCAM family: three members with different VASE usage and distinct localization. Molecular and cellular neurosciences. 18(1):119-130
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