Gene
odc1
- ID
- ZDB-GENE-010816-1
- Name
- ornithine decarboxylase 1
- Symbol
- odc1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable ornithine decarboxylase activity. Acts upstream of or within eye photoreceptor cell development. Predicted to be active in cytoplasm. Is expressed in neuromast and ovary. Orthologous to human ODC1 (ornithine decarboxylase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55204 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-odc1 | Herzog et al., 2020 | |
| CRISPR2-odc1 | Herzog et al., 2020 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bachmann-Bupp syndrome | 619075 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR022653 | Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site |
| Conserved_site | IPR022657 | Orn/DAP/Arg decarboxylase 2, conserved site |
| Domain | IPR022643 | Orn/DAP/Arg decarboxylase 2, C-terminal |
| Domain | IPR022644 | Orn/DAP/Arg decarboxylase 2, N-terminal |
| Family | IPR000183 | Ornithine/DAP/Arg decarboxylase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Alanine racemase/group IV decarboxylase, C-terminal | Orn/DAP/Arg decarboxylase 2, conserved site | Orn/DAP/Arg decarboxylase 2, C-terminal | Orn/DAP/Arg decarboxylase 2, N-terminal | Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site | Ornithine/DAP/Arg decarboxylase | Ornithine decarboxylase | PLP-binding barrel |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9DGJ4 | InterPro | 461 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-odc1 | monoclonal | IgG2b | Mouse |
|
Sigma-Aldrich
|
3 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-378J2 | ZFIN Curated Data | |
| Encodes | BAC END | zk16b16.t7 | ||
| Encodes | EST | fc54f04 | ||
| Encodes | EST | fi06d08 | ||
| Encodes | cDNA | MGC:55204 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77567 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113953 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192430 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131801 (1) | 2154 nt | ||
| Genomic | GenBank:CU638706 (2) | 40247 nt | ||
| Polypeptide | UniProtKB:Q9DGJ4 (1) | 461 aa |
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Cadiz Diaz, A., Schmidt, N.A., Yamazaki, M., Hsieh, C.J., Lisse, T.S., Rieger, S. (2022) Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2115009119
- Denans, N., Tran, N.T.T., Swall, M.E., Diaz, D.C., Blanck, J., Piotrowski, T. (2022) An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Nature communications. 13:5356
- Kumar, J., Kumar, M., Sharma, S., Srivastava, N., Singh, R., Hussain, M.A., Mazumder, S. (2022) Th1-Th2 and M1-M2 interplay sculpt Aeromonas hydrophila pathogenesis in zebrafish (Danio rerio). Fish & shellfish immunology. 127:357-365
- Rawson, A., Saxena, V., Gao, H., Hooks, J., Xuei, X., McGuire, P., Hato, T., Hains, D.S., Anderson, R.M., Schwaderer, A.L. (2022) A Pilot Single Cell Analysis of the Zebrafish Embryo Cellular Responses to Uropathogenic Escherichia coli Infection. Pathogens & immunity. 7:1-18
- Yang, H., Huang, Y., Li, Z., Guo, Y., Li, S., Huang, H., Yang, X., Li, G., Chen, H. (2022) Effects of Dietary Supplementation with Aurantiochytrium sp. on Zebrafish Growth as Determined by Transcriptomics. Animals : an open access journal from MDPI. 12(20):
- Banerjee, B., Khrystoforova, I., Polis, B., Zvi, I.B., Karasik, D. (2021) Acute hypoxia elevates arginase 2 and induces polyamine stress response in zebrafish via evolutionarily conserved mechanism. Cellular and molecular life sciences : CMLS. 79(1):41
- Nakagawa, H., Kuroda, J., Aramaki, T., Kondo, S. (2021) Mechanical role of actinotrichia in shaping the caudal fin of zebrafish. Developmental Biology. 481:52-63
- Gross-Thebing, S., Truszkowski, L., Tenbrinck, D., Sánchez-Iranzo, H., Camelo, C., Westerich, K.J., Singh, A., Maier, P., Prengel, J., Lange, P., Hüwel, J., Gaede, F., Sasse, R., Vos, B.E., Betz, T., Matis, M., Prevedel, R., Luschnig, S., Diz-Muñoz, A., Burger, M., Raz, E. (2020) Using migrating cells as probes to illuminate features in live embryonic tissues. Science advances. 6(49):
- Herzog, C., Greenald, D., Larraz, J., Keatinge, M., Herrgen, L. (2020) RNA-seq analysis and compound screening highlight multiple signalling pathways regulating secondary cell death after acute CNS injury in vivo. Biology Open. 9(5):
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