Gene
lmo4a
- ID
- ZDB-GENE-010702-1
- Name
- LIM domain only 4a
- Symbol
- lmo4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within embryonic camera-type eye development and forebrain development. Is expressed in several structures, including brain; cardiovascular system; germ ring; mesoderm; and neural keel. Orthologous to human LMO4 (LIM domain only 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu232 (23 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-lmo4a | Sun et al., 2023 | |
CRISPR2-lmo4a | Sun et al., 2023 | |
CRISPR3-lmo4a | Sun et al., 2023 | |
CRISPR4-lmo4a | Sun et al., 2023 | |
MO1-lmo4a | N/A | (2) |
MO2-lmo4a | N/A | (2) |
MO3-lmo4a | N/A | (2) |
MO4-lmo4a | N/A | Sun et al., 2023 |
TALEN1-lmo4a | Dobrzycki et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | LMO/RBTN Transcription Factors | Zinc finger, LIM-type |
---|---|---|---|---|
UniProtKB:A0A2R8RLI6 | InterPro | 166 | ||
UniProtKB:Q8QG63 | InterPro | 167 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-2N12 | ZFIN Curated Data | |
Encodes | EST | eu232 | Thisse et al., 2005 | |
Encodes | EST | ibd2576 | ZFIN Curated Data | |
Encodes | EST | ibd5151 | ZFIN Curated Data | |
Encodes | cDNA | MGC:55192 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191201 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_177984 (1) | 1927 nt | ||
Genomic | GenBank:BX324171 (1) | 151068 nt | ||
Polypeptide | UniProtKB:Q8QG63 (1) | 167 aa |
- Sun, L., Ping, L., Gao, R., Zhang, B., Chen, X. (2023) lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway. Genes. 14(7):
- Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375
- Dobrzycki, T., Krecsmarik, M., Bonkhofer, F., Patient, R., Monteiro, R. (2018) An optimised pipeline for parallel image-based quantification of gene expression and genotyping after in situ hybridisation.. Biology Open. 7(4)
- Wagner, D.E., Weinreb, C., Collins, Z.M., Briggs, J.A., Megason, S.G., Klein, A.M. (2018) Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science (New York, N.Y.). 360(6392):981-987
- Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70
- Arslan-Ergul, A., and Adams, M.M. (2014) Gene expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic. BMC Neuroscience. 15:29
- McCollum, C.W., Amin, S.R., Pauerstein, P., and Lane, M.E. (2007) A zebrafish LMO4 ortholog limits the size of the forebrain and eyes through negative regulation of six3b and rx3. Developmental Biology. 309(2):373-385
- Meier, N., Krpic, S., Rodriguez, P., Strouboulis, J., Monti, M., Krijgsveld, J., Gering, M., Patient, R., Hostert, A., and Grosveld, F. (2006) Novel binding partners of Ldb1 are required for haematopoietic development. Development (Cambridge, England). 133(24):4913-4923
- Lane, M.E., Runko, A.P., Roy, N.M., and Sagerström, C.G. (2002) Dynamic expression and regulation by Fgf8 and Pou2 of the zebrafish LIM-only gene, lmo4. Mechanisms of Development. (Suppl.) 119:S185-S189
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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