Gene

zeb1b

ID
ZDB-GENE-010621-1
Name
zinc finger E-box binding homeobox 1b
Symbol
zeb1b Nomenclature History
Previous Names
  • zeb1
  • kheper (1)
  • tcf8 (1)
  • ZFH/[d]EF1 (1)
  • zfhx1 (1)
  • zfhx1a (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including gastrulation; regulation of cell-cell adhesion involved in gastrulation; and regulation of gastrulation. Predicted to localize to nucleus. Is expressed in several structures, including cranial ganglion; hypoblast; neural plate; pharyngeal arch; and segmental plate. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zeb1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Fuchs' endothelial dystrophy Alliance Corneal dystrophy, Fuchs endothelial, 6 613270
posterior polymorphous corneal dystrophy 3 Alliance Corneal dystrophy, posterior polymorphous, 3 609141
Associated With zeb1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001356 Homeobox domain
Domain IPR008598 Drought induced 19 protein type, zinc-binding domain
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Drought induced 19 protein type, zinc-binding domain Homeobox domain Homeobox-like domain superfamily Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:Q9DEH7 1078
UniProtKB:A0A2R8QF92 1074
UniProtKB:F1QPM7 1078
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations