Gene
zeb1b
- ID
- ZDB-GENE-010621-1
- Name
- zinc finger E-box binding homeobox 1b
- Symbol
- zeb1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity and metal ion binding activity. Involved in gastrulation; regulation of cell motility; and regulation of cell-cell adhesion involved in gastrulation. Predicted to localize to nucleus. Is expressed in several structures, including cranial ganglion; hypoblast; neural plate; pharyngeal arch; and segmental plate. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu530 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fuchs' endothelial dystrophy | Alliance | Corneal dystrophy, Fuchs endothelial, 6 | 613270 |
| posterior polymorphous corneal dystrophy 3 | Alliance | Corneal dystrophy, posterior polymorphous, 3 | 609141 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Drought induced 19 protein type, zinc-binding domain | Homeobox domain | Homeobox-like domain superfamily | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QF92
|
1074 | |||||
|
UniProtKB:F1QPM7
|
1078 | |||||
|
UniProtKB:Q9DEH7
|
1078 |
Interactions and Pathways
No data available
Plasmids
No data available