ZFIN is now using GRCz12tu for Genomic Data
Gene
zeb1b
- ID
- ZDB-GENE-010621-1
- Name
- zinc finger E-box binding homeobox 1b
- Symbol
- zeb1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including gastrulation; regulation of cell-cell adhesion involved in gastrulation; and regulation of gastrulation. Predicted to be located in nucleus. Is expressed in several structures, including cranial ganglion; hypoblast; intestine; neural plate; and segmental plate. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu530 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fuchs' endothelial dystrophy | Alliance | Corneal dystrophy, Fuchs endothelial, 6 | 613270 |
| posterior polymorphous corneal dystrophy 3 | Alliance | Corneal dystrophy, posterior polymorphous, 3 | 609141 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001356 | Homeodomain |
| Domain | IPR008598 | Drought induced 19 protein type, zinc-binding domain |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Family | IPR051574 | Zinc finger E-box-binding homeobox |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
| Homologous_superfamily | IPR036236 | Zinc finger C2H2 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Drought induced 19 protein type, zinc-binding domain | Homedomain-like superfamily | Homeodomain | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger E-box-binding homeobox |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QE24 | InterPro | 1064 | ||||||
| UniProtKB:Q9DEH7 | InterPro | 1078 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers