Gene
bco1
- ID
- ZDB-GENE-010508-1
- Name
- beta-carotene oxygenase 1
- Symbol
- bco1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables beta-carotene 15,15'-dioxygenase activity. Acts upstream of or within eye photoreceptor cell differentiation and hindbrain development. Is expressed in gut; liver; neural crest; ovary; and xanthophore. Orthologous to human BCO1 (beta-carotene oxygenase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56569 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| carotenemia | Alliance | ?Hypercarotenemia and vitamin A deficiency, autosomal dominant | 115300 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR004294 | Carotenoid oxygenase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Carotenoid oxygenase |
|---|---|---|---|
| UniProtKB:Q7ZTS0 | InterPro | 516 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-71F13 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-356O14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56569 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131798 (1) | 1896 nt | ||
| Genomic | GenBank:CU856172 (2) | 99708 nt | ||
| Polypeptide | UniProtKB:Q7ZTS0 (1) | 516 aa |
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Saunders, L.M., Mishra, A.K., Aman, A.J., Lewis, V.M., Toomey, M.B., Packer, J.S., Qiu, X., McFaline-Figueroa, J.L., Corbo, J.C., Trapnell, C., Parichy, D.M. (2019) Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. eLIFE. 8:
- England, S.J., Campbell, P.C., Banerjee, S., Swanson, A.J., Lewis, K.E. (2017) Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes.. Frontiers in cell and developmental biology. 5:5
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Wu, M., Liu, S., Hu, L., Qu, H., Pan, C., Lei, P., Shen, Y., Yang, M. (2017) Global transcriptomic analysis of zebrafish in response to embryonic exposure to three antidepressants, amitriptyline, fluoxetine and mianserin. Aquatic toxicology (Amsterdam, Netherlands). 192:274-283
- Helgeland, H., Sandve, S.R., Torgersen, J.S., Halle, M.K., Sundvold, H., Omholt, S., and Våge, D.I. (2014) The evolution and functional divergence of the beta-carotene oxygenase gene family in teleost fish--exemplified by Atlantic salmon. Gene. 543(2):268-74
- Baraban, S.C., Dinday, M.T., and Hortopan, G.A. (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nature communications. 4:2410
- Levi, L., Ziv, T., Admon, A., Levavi-Sivan, B., and Lubzens, E. (2012) Insight into molecular pathways of retinal metabolism, associated with vitellogenesis in zebrafish. American journal of physiology. Endocrinology and metabolism. 302(6):E626-644
- Biehlmaier, O., Lampert, J.M., Lintig, J.V., and Kohler, K. (2005) Photoreceptor morphology is severely affected in the beta,beta-carotene-15,15'-oxygenase (bcox) zebrafish morphant. The European journal of neuroscience. 21(1):59-68
- Lampert, J.M., Holzschuh, J., Hessel, S., Driever, W., Vogt, K., and von Lintig, J. (2003) Provitamin A conversion to retinal via the beta,beta-carotene-15,15'-oxygenase (bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis. Development (Cambridge, England). 130(10):2173-2186
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