glrba

ID

ZDB-GENE-010410-2

Name

glycine receptor, beta a

Symbol

glrba Nomenclature History

Previous Names

glrb1 (1)
glrb
[b]Z (1)
etID17582.1 (1)
fj42f03
GlyR [b]Z (1)
wu:fj42f03 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chloride transmembrane transport; glycinergic synaptic transmission; and regulation of membrane potential. Predicted to act upstream of or within chloride transport and monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in hindbrain and spinal cord. Human ortholog(s) of this gene implicated in hyperekplexia 2. Orthologous to human GLRB (glycine receptor beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With glrba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hyperekplexia 2	Alliance	Hyperekplexia 2	614619

Associated With glrba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018000	Neurotransmitter-gated ion-channel, conserved site
Domain	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Domain	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain
Domain	IPR047029	Glycine receptor subunit beta, transmembrane domain
Family	IPR006201	Neurotransmitter-gated ion-channel
Family	IPR008060	Glycine receptor beta
Homologous_superfamily	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily
Homologous_superfamily	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Homologous_superfamily	IPR038050	Neuronal acetylcholine receptor

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M6YXY6	InterPro	493
UniProtKB:Q9DES8	InterPro	498
UniProtKB:A0AB32TQ72	InterPro	494
UniProtKB:A0AB32TQY6	InterPro	493
UniProtKB:A0AB32TUJ6	InterPro	499