Gene
cldnb
- ID
- ZDB-GENE-010328-2
- Name
- claudin b
- Symbol
- cldnb Nomenclature History
- Previous Names
-
- cldn30c (1)
- wu:fa66b05
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Acts upstream of or within neuromast development and regulation of sodium ion transport. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including EVL; digestive system; integument; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in ovarian cancer and pancreatic cancer. Orthologous to human CLDN4 (claudin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 37 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92382 (21 images)
- eu135 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Kwong et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb154 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cldnb | Zebrafish Nomenclature Committee | |
| MO1-cldnb | N/A | (3) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Claudin | PMP-22/EMP/MP20/Claudin |
|---|---|---|---|---|
| UniProtKB:Q90XR8 | InterPro | 215 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(cldnb:EGFP) |
|
| 1 | (4) | |
| Tg(-8.0cldnb:LY-EGFP) |
|
| 1 | (178) | |
| Et(cldnb:LOX2272-LOXP-Tomato-LOX2272-Cerulean-LOXP-EYFP) |
|
| 2 | Hughes et al., 2022 | |
| Tg2(cldnb:EGFP) |
|
| 1 | (3) | |
| Tg(-8.0cldnb:GAL4-VP16) |
|
| 1 | (2) | |
| Tg(-8.0cldnb:H2A-mCherry) |
|
| 1 | (7) | |
| Tg(-8.0cldnb:NTR-KikGR,myl7:EGFP) |
|
| 1 | Lin et al., 2022 | |
| Tg(cldnb:ERT2-GAL4) |
|
| 1 | Pinto-Teixeira et al., 2015 | |
| Tg(cldnb:ERT2-GAL4-VP16) |
|
| 1 | (3) | |
| Tg(cldnb:EYFP) |
|
| 1 | Hughes et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-54M16 | ZFIN Curated Data | |
| Encodes | EST | eu135 | Thisse et al., 2005 | |
| Encodes | EST | fa66b05 | ||
| Encodes | cDNA | MGC:92382 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191160 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131763 (1) | 1145 nt | ||
| Genomic | GenBank:CR847847 (1) | 76887 nt | ||
| Polypeptide | UniProtKB:Q90XR8 (1) | 215 aa |
No data available
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- Hughes, S.M., Escaleira, R.C., Wanders, K., Koth, J., Wilkinson, D.G., Xu, Q. (2022) Clonal behaviour of myogenic precursor cells throughout the vertebrate lifespan. Biology Open. 11(8):
- Lin, M.J., Lee, C.M., Hsu, W.L., Chen, B.C., Lee, S.J. (2022) Macrophages Break Interneuromast Cell Quiescence by Intervening in the Inhibition of Schwann Cells in the Zebrafish Lateral Line. Frontiers in cell and developmental biology. 10:907863
- Marsay, K.S., Greaves, S., Mahabaleshwar, H., Ho, C.M., Roehl, H., Monk, P.N., Carney, T.J., Partridge, L.J. (2021) Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration. PLoS One. 16:e0260372
- Phatak, M., Kulkarni, S., Miles, L.B., Anjum, N., Dworkin, S., Sonawane, M. (2021) Grhl3 promotes retention of epidermal cells under endocytic stress to maintain epidermal architecture in zebrafish. PLoS Genetics. 17:e1009823
- Dalle Nogare, D.E., Natesh, N., Vishwasrao, H.D., Shroff, H., Chitnis, A.B. (2020) Zebrafish Posterior Lateral Line primordium migration requires interactions between a superficial sheath of motile cells and the skin. eLIFE. 9:
- Kozak, E.L., Palit, S., Miranda-Rodríguez, J.R., Janjic, A., Böttcher, A., Lickert, H., Enard, W., Theis, F.J., López-Schier, H. (2020) Epithelial Planar Bipolarity Emerges from Notch-Mediated Asymmetric Inhibition of Emx2. Current biology : CB. 30(6):1142-1151.e6
- Li, C., Barton, C., Henke, K., Daane, J., Treaster, S., Caetano-Lopez, J., Tanguay, R.L., Harris, M. (2020) Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. eLIFE. 9:
- Solis, C.J., Hamilton, M.K., Caruffo, M., Garcia-Lopez, J.P., Navarrete, P., Guillemin, K., Feijoo, C.G. (2020) Intestinal Inflammation Induced by Soybean Meal Ingestion Increases Intestinal Permeability and Neutrophil Turnover Independently of Microbiota in Zebrafish. Frontiers in immunology. 11:1330
- Lin, X., Zhou, Q., Zhao, C., Lin, G., Xu, J., Wen, Z. (2019) An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis. Developmental Cell. 49(4):605-617.e5
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