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Gene

map2k6

ID
ZDB-GENE-010202-3
Name
mitogen-activated protein kinase kinase 6
Symbol
map2k6 Nomenclature History
Previous Names
  • map2k3 (1)
  • MKK3 (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable MAP kinase kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm; cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With map2k6 Human Ortholog
No data available
Associated With map2k6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:B2GTB0 363
UniProtKB:A0A286Y813 363
UniProtKB:Q9DGE0 361
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Woods, et al. (2005. Genome Res. 15:1307-1914.) reported orthology to MAP2K3 supported by amino acid sequence identity. Fujii, et al 2000. (J. Cell Biol. 150:1335-1347.) reported orthology to human MAP2K3 based on AA and XH.
Citations