Gene

cdk5

ID
ZDB-GENE-010131-2
Name
cyclin-dependent kinase 5
Symbol
cdk5 Nomenclature History
Previous Names
  • zgc:101604
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Exhibits cyclin-dependent protein serine/threonine kinase activity and histone kinase activity. Involved in several processes, including nervous system development; retina morphogenesis in camera-type eye; and type B pancreatic cell differentiation. Predicted to localize to cytoplasm and nucleus. Is expressed in blastomere; central nervous system; immature eye; musculature system; and neural plate. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly. Orthologous to human CDK5 (cyclin dependent kinase 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdk5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lissencephaly 7 with cerebellar hypoplasia Alliance ?Lissencephaly 7 with cerebellar hypoplasia 616342
Associated With cdk5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q5U3V4 292
UniProtKB:Q9DE44 292
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cdk5 polyclonal IgG Rabbit
  • WB
Santa Cruz Biotechnology, Inc.
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations