ZFIN is now using GRCz12tu for Genomic Data
Gene
ctbp1l
- ID
- ZDB-GENE-010130-1
- Name
- C-terminal binding protein 1-like
- Symbol
- ctbp1l Nomenclature History
- Previous Names
-
- CtBP1 (1)
- ctbp1
- wu:fi43a11
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable several functions, including transcription coactivator activity; transcription coregulator binding activity; and transcription corepressor activity. Acts upstream of or within retinoic acid receptor signaling pathway. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in tooth disease. Orthologous to human CTBP1 (C-terminal binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55227 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Delacruz et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome | 617915 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR029752 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 |
| Conserved_site | IPR029753 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site |
| Domain | IPR006139 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain |
| Domain | IPR006140 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain |
| Family | IPR043322 | C-terminal binding protein |
| Family | IPR051638 | C-terminal-binding dehydrogenase |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C-terminal-binding dehydrogenase | C-terminal binding protein | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZU55 | InterPro | 449 | |||||||
| UniProtKB:A0A8M2BKF1 | InterPro | 498 | |||||||
| UniProtKB:A0A8M1PBY6 | InterPro | 449 | |||||||
| UniProtKB:A0AC58H6S6 | InterPro | 449 | |||||||
| UniProtKB:A0AC58H6T0 | InterPro | 479 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers