Gene
vsx2
- ID
- ZDB-GENE-001222-1
- Name
- visual system homeobox 2
- Symbol
- vsx2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Exhibits sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and regulation of neural retina development. Predicted to localize to nucleus. Is expressed in nervous system; neural tube; optic cup; and optic vesicle. Human ortholog(s) of this gene implicated in blindness and isolated microphthalmia 2. Orthologous to human VSX2 (visual system homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 65 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66294 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated microphthalmia 2 | Alliance | Microphthalmia, isolated 2 | 610093 |
| Microphthalmia with coloboma 3 | 610092 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CVC domain | Homeobox, conserved site | Homeobox domain | Homeobox-like domain superfamily | OAR domain |
|---|---|---|---|---|---|---|
|
UniProtKB:O42477
|
393 | |||||
|
UniProtKB:F1QQE7
|
372 | |||||
|
UniProtKB:B2GP41
|
372 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-vsx2 | polyclonal | IgG | Sheep |
|
Exalpha Biologicals, Inc
|
1 |
Plasmids
No data available