Gene
nrf1
- ID
- ZDB-GENE-001221-1
- Name
- nuclear respiratory factor 1
- Symbol
- nrf1 Nomenclature History
- Previous Names
-
- nrf
- nrl (1)
- not really finished
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in neural retina development. Acts upstream of or within several processes, including cellular response to cold; photoreceptor cell maintenance; and response to activity. Predicted to be active in nucleus. Is expressed in heart; nervous system; optic cup; and visceral fat. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human NRF1 (nuclear respiratory factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55915 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NRF1/Ewg family | Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain |
|---|---|---|---|---|
| UniProtKB:Q90X44 | InterPro | 514 |
Interactions and Pathways
No data available
Plasmids
No data available