Gene
nrf1
- ID
- ZDB-GENE-001221-1
- Name
- nuclear respiratory factor 1
- Symbol
- nrf1 Nomenclature History
- Previous Names
-
- nrf
- nrl (1)
- not really finished
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in neural retina development. Acts upstream of or within several processes, including cellular response to cold; photoreceptor cell maintenance; and response to activity. Predicted to be active in nucleus. Is expressed in heart; nervous system; optic cup; and visceral fat. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human NRF1 (nuclear respiratory factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55915 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi399Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la028975Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9538 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20242 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33432 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NRF1/Ewg family | Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain |
|---|---|---|---|---|
| UniProtKB:Q90X44 | InterPro | 514 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-3C13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55915 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328540 (1) | 3013 nt | ||
| Genomic | GenBank:AL590150 (2) | 148777 nt | ||
| Polypeptide | UniProtKB:Q90X44 (1) | 514 aa |
- Subba, R., Fasciolo, G., Geremia, E., Muscari Tomajoli, M.T., Petito, A., Carrella, S., Mondal, A.C., Napolitano, G., Venditti, P. (2024) Simultaneous induction of systemic hyperglycaemia and stress impairs brain redox homeostasis in the adult zebrafish. Archives of biochemistry and biophysics. 759:110101
- Kurchaba, N., Charette, J.M., LeMoine, C.M.R. (2022) Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscle. American journal of physiology. Regulatory, integrative and comparative physiology. 323(3):R319-R330
- Zou, Y.Y., Chen, Z.L., Sun, C.C., Yang, D., Zhou, Z.Q., Xiao, Q., Peng, X.Y., Tang, C.F. (2022) A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity. Nutrients. 14(9)
- Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33
- Giarmarco, M.M., Brock, D.C., Robbings, B.M., Cleghorn, W.M., Tsantilas, K.A., Kuch, K.C., Ge, W., Rutter, K.M., Parker, E.D., Hurley, J.B., Brockerhoff, S.E. (2020) Daily mitochondrial dynamics in cone photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. 117:28816-28827
- Shao, X., Fu, Y., Ma, J., Li, X., Lu, C., Zhang, R. (2020) Functional alterations and transcriptomic changes during zebrafish cardiac aging. Biogerontology. 21(5):637-652
- Zhuang, J., Pan, Z.J., Mengqiu-Li, ., Hong, F.S., Zhu, C.K., Wu, N., Chang, G., Wang, H., Zhao, X.X. (2020) BDE-47 induced apoptosis in zebrafish embryos through mitochondrial ROS-mediated JNK signaling. Chemosphere. 258:127385
- Collins, M.M., Ahlberg, G., Hansen, C.V., Guenther, S., Marín-Juez, R., Sokol, A.M., El-Sammak, H., Piesker, J., Hellsten, Y., Olesen, M.S., Stainier, D.Y.R., Lundegaard, P.R. (2019) Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model. Proceedings of the National Academy of Sciences of the United States of America. 116(48):24115-24121
- Collodet, C., Foretz, M., Deak, M., Bultot, L., Metairon, S., Viollet, B., Lefebvre, G., Raymond, F., Parisi, A., Civiletto, G., Gut, P., Descombes, P., Sakamoto, K. (2019) AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(11):12374-12391
- Northam, C., LeMoine, C.M.R. (2019) Metabolic regulation by the PGC-1α and PGC-1β coactivators in larval zebrafish (Danio rerio). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 234:60-67
1 - 10 of 31
Show