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Gene

atp1a2a

ID
ZDB-GENE-001212-6
Name
ATPase Na+/K+ transporting subunit alpha 2a
Symbol
atp1a2a Nomenclature History
Previous Names
  • atp[a]2 (1)
  • cb702 (1)
  • fa10d04
  • fa10d05
  • wu:fa10d05 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within several processes, including animal organ development; heart contraction; and thigmotaxis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including Kupffer's vesicle; brain; heart; musculature system; and pronephric duct. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; familial hemiplegic migraine 2; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atp1a2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alternating hemiplegia of childhood Alliance Alternating hemiplegia of childhood 1 104290
familial hemiplegic migraine 2 Alliance Migraine, familial basilar 602481
familial hemiplegic migraine 2 Alliance Migraine, familial hemiplegic, 2 602481
Associated With atp1a2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004014 Cation-transporting P-type ATPase, N-terminal
Domain IPR006068 Cation-transporting P-type ATPase, C-terminal
Family IPR001757 P-type ATPase
Family IPR005775 P-type ATPase subfamily IIC, subunit alpha
Homologous_superfamily IPR008250 P-type ATPase, A domain superfamily
Homologous_superfamily IPR023214 HAD superfamily
Homologous_superfamily IPR023298 P-type ATPase, transmembrane domain superfamily
Homologous_superfamily IPR023299 P-type ATPase, cytoplasmic domain N
Homologous_superfamily IPR036412 HAD-like superfamily
PTM IPR018303 P-type ATPase, phosphorylation site
Domain Details Per Protein
Protein Length Cation-transporting P-type ATPase, C-terminal Cation-transporting P-type ATPase, N-terminal HAD-like superfamily HAD superfamily P-type ATPase P-type ATPase, A domain superfamily P-type ATPase, cytoplasmic domain N P-type ATPase, phosphorylation site P-type ATPase subfamily IIC, subunit alpha P-type ATPase, transmembrane domain superfamily
UniProtKB:B0S5Q5 1017
UniProtKB:A0A2R8Q7T9 982
UniProtKB:A0A2R8Q8K8 1013
UniProtKB:Q90X34 1017
UniProtKB:Q9DGL5 1017
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations