Gene
atp1a1a.4
- ID
- ZDB-GENE-001212-4
- Name
- ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 4
- Symbol
- atp1a1a.4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable P-type sodium:potassium-exchanging transporter activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; immature eye; integument; nervous system; and pronephros. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb708 (19 images)
- eu300 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa13870 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14079 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14454 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17542 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19396 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19397 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32576 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32577 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39529 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44502 | Allele with one point mutation | Unknown | Unknown | ENU |
1 - 10 of 11
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-atp1a1a.4 | China Zebrafish Resource Center (CZRC) |
1 - 1 of 1
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 2DD | Alliance | Charcot-Marie-Tooth disease, axonal, type 2DD | 618036 |
| Hypomagnesemia, seizures, and impaired intellectual development 2 | 618314 |
1 - 2 of 2
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004014 | Cation-transporting P-type ATPase, N-terminal |
| Domain | IPR006068 | Cation-transporting P-type ATPase, C-terminal |
| Domain | IPR044492 | P-type ATPase, haloacid dehalogenase domain |
| Family | IPR001757 | P-type ATPase |
| Family | IPR005775 | P-type ATPase subfamily IIC, subunit alpha |
1 - 5 of 12 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Cation transport ATPase (P-type) | Cation-transporting P-type ATPase, C-terminal | Cation-transporting P-type ATPase, N-terminal | HAD-like superfamily | HAD superfamily | P-type ATPase | P-type ATPase, A domain superfamily | P-type ATPase, cytoplasmic domain N | P-type ATPase, haloacid dehalogenase domain | P-type ATPase, phosphorylation site | P-type ATPase subfamily IIC, subunit alpha | P-type ATPase, transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q90X33 | InterPro | 1024 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp1a1a.4-201
(1)
|
Ensembl | 3,246 nt | ||
| ncRNA |
atp1a1a.4-002
(1)
|
Ensembl | 887 nt | ||
| ncRNA |
atp1a1a.4-003
(1)
|
Ensembl | 664 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(atp1a1a.4:EGFP) |
|
| 1 | (18) |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-208K14 | ZFIN Curated Data | |
| Encodes | EST | cb708 | (2) | |
| Encodes | EST | eu300 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:64170 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131689 (1) | 3270 nt | ||
| Genomic | GenBank:CU185242 (1) | 180192 nt | ||
| Polypeptide | UniProtKB:Q90X33 (1) | 1024 aa |
- Abu Obaid, A., Ivandic, I., Korsching, S.I. (2024) Deciphering the function of the fifth class of Gα proteins: regulation of ionic homeostasis as unifying hypothesis. Cellular and molecular life sciences : CMLS. 81:213213
- Perens, E.A., Yelon, D. (2024) Drivers of Vessel Progenitor Fate Define Intermediate Mesoderm Dimensions by Inhibiting Kidney Progenitor Specification. Developmental Biology. 517:126-139
- Uribe-Montes, L.C., Sanabria-Camargo, C.A., Piñeros-Romero, C.C., Otálora-Tarazona, S., Ávila-Jiménez, E., Acosta-Virgüez, E., Garavito-Aguilar, Z.V. (2024) Fibronectin and Hand2 influence tubulogenesis during pronephros development and mesonephros regeneration in zebrafish (Danio rerio). PLoS One. 19:e0307390e0307390
- Mao, K., Li, X., Chen, Z., Dong, X., Zhangsun, D., Zhu, X., Luo, S. (2022) α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal. Frontiers in pharmacology. 13:802917
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- Perens, E.A., Diaz, J.T., Quesnel, A., Askary, A., Crump, J.G., Yelon, D. (2021) osr1 couples intermediate mesoderm cell fate with temporal dynamics of vessel progenitor cell differentiation. Development (Cambridge, England). 148(15):
- Esbaugh, A.J., Brix, K.V., Grosell, M. (2019) Na+ K+ ATPase isoform switching in zebrafish during transition to dilute freshwater habitats. Proceedings. Biological sciences. 286:20190630
- Naylor, R.W., Chang, H.G., Qubisi, S., Davidson, A.J. (2018) A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusion. eLIFE. 7:
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Kuechlin, S., Schoels, M., Slanchev, K., Lassmann, S., Walz, G., Yakulov, T.A. (2017) EpCAM controls morphogenetic programs during zebrafish pronephros development. Biochemical and Biophysical Research Communications. 487(2):209-215
1 - 10 of 32
Show