ZFIN ID: ZDB-GENE-001207-7
Gene Name: eph receptor A4a
Gene Symbol: epha4a    Nomenclature History

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Previous Names: EphA4, cb246, ek2, etID309926.2 (1), rtk1, sb:cb246, zek2, zgc:109882

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have transmembrane-ephrin receptor activity. Involved in several processes, including cell-cell recognition; nervous system development; and optic vesicle morphogenesis. Predicted to localize to the integral component of plasma membrane; neuron projection; and receptor complex. Is expressed in several structures, including central nervous system; germ ring; mesoderm; neural keel; and neural tube. Orthologous to human EPHA4 (EPH receptor A4).
Genome Resources: Alliance (1),  Gene:64271 (1),  Ensembl(GRCz11):ENSDARG00000054454 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023682Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa111 Point Mutation Unknown Unknown ENU
    sa208 Point Mutation Unknown Premature Stop ENU
    sa9644 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9998 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15903 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17262 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25876 Point Mutation Unknown Splice Site ENU
    sa31294 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39898 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-epha4a
    1
    MO1-epha4a N/A 8
    MO2-epha4a N/A 2
    MO3-epha4a N/A 2
    DISEASE ASSOCIATED WITH epha4a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH epha4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of axon extension (more)
    Cellular Component early endosome (more)
    Molecular Function ATP binding (more)
    GO Terms (all 32)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001090 Ephrin receptor ligand binding domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Conserved_site IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    Domain IPR001660 Sterile alpha motif domain
    Domain IPR003961 Fibronectin type III
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
    Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Family IPR016257 Ephrin receptor type-A /type-B
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Domain IPR027936 Ephrin receptor, transmembrane domain
    Domain IPR034270 Ephrin type-A receptor 4, ligand binding domain
    Homologous_superfamily IPR036116 Fibronectin type III superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA epha4a-202 (1)    Ensembl 985
    epha4a-203 (1)    Ensembl 3387
    ncRNA epha4a-003 (1) 1693
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM epha4a No data available
    MARKER RELATIONSHIPS
    epha4a Contained in: [BAC] CH73-275D12 (1), CH73-362D4 (1)
    epha4a Encodes: [EST] cb246 (order this), eu671 (1), fi31g02
    [cDNA] MGC:109882 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001005919 (1) 2961 bp
    Genomic GenBank:BX511156 (1) 158656 bp
    Select Tool
    Polypeptide UniProtKB:F8W481 (1) 995 aa
    Sequence Information (all 48)
    ORTHOLOGY for epha4a ( Chr: 2 )
    CITATIONS (113)