Gene

epha4a

ID
ZDB-GENE-001207-7
Name
eph receptor A4a
Symbol
epha4a Nomenclature History
Previous Names
  • EphA4
  • cb246
  • ek2
  • etID309926.2 (1)
  • rtk1
  • sb:cb246
  • zek2
  • zgc:109882
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have transmembrane-ephrin receptor activity. Involved in several processes, including nervous system development; optic vesicle morphogenesis; and regulation of myelination. Predicted to localize to integral component of plasma membrane; neuron projection; and receptor complex. Is expressed in several structures, including central nervous system; germ ring; mesoderm; neural keel; and neural tube. Orthologous to human EPHA4 (EPH receptor A4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
72 figures from 49 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With epha4a Human Ortholog
No data available
Associated With epha4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001090 Ephrin receptor ligand binding domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001660 Sterile alpha motif domain
Domain IPR003961 Fibronectin type III
Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR027936 Ephrin receptor, transmembrane domain
Domain IPR030602 Ephrin type-A receptor 4, SAM domain
Domain IPR034270 Ephrin type-A receptor 4, ligand binding domain
Family IPR016257 Ephrin receptor type-A /type-B
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Ephrin receptor ligand binding domain Ephrin receptor, transmembrane domain Ephrin receptor type-A /type-B Ephrin type-A receptor 4, ligand binding domain Ephrin type-A receptor 4, SAM domain Fibronectin type III Fibronectin type III superfamily Galactose-binding-like domain superfamily Growth factor receptor cysteine-rich domain superfamily Immunoglobulin-like fold Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Sterile alpha motif domain Sterile alpha motif/pointed domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase ephrin type A/B receptor-like Tyrosine-protein kinase, receptor class V, conserved site
UniProtKB:Q5ZEW1 986
UniProtKB:A0A286Y8S1 986
UniProtKB:O13148 292
UniProtKB:A0A0B5JW53 546
UniProtKB:F8W2C8 318
UniProtKB:F1QIM7 937
UniProtKB:F8W481 995
UniProtKB:Q4KMK2 937
UniProtKB:A2BG00 720
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations