Gene
ctsk
- ID
- ZDB-GENE-001205-4
- Name
- cathepsin K
- Symbol
- ctsk Nomenclature History
- Previous Names
-
- etID33526.16 (1)
- wu:fa95f03
- wu:fb08b05
- zgc:110367
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within bone morphogenesis; cartilage development; and response to mechanical stimulus. Predicted to be located in plasma membrane. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including cardiovascular system; fin; head; lateral line system; and mesoderm. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110367 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ctsk | Kague et al., 2021 | |
| CRISPR2-ctsk | Kague et al., 2021 | |
| MO1-ctsk | N/A | (3) |
| MO2-ctsk | N/A | Petrey et al., 2012 |
| TALEN1-ctsk | Lu et al., 2020 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pycnodysostosis | Alliance | Pycnodysostosis | 265800 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
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Domain Details Per Protein
| Protein | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q568D6
|
333 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(ctsk:Citrine) |
|
| 1 | (7) | |
| Tg(ctsk:Hsa.PTDSS1-IRES-NLS-mCherry,myl7:EGFP) |
|
| 2 | Seda et al., 2019 | |
| Tg(ctsk:Hsa.PTDSS1_Q353R-IRES-NLS-mCherry,myl7:EGFP) |
|
| 1 | Seda et al., 2019 | |
| Tg(ctsk:MA-EGFP) |
|
| 1 | Han et al., 2021 | |
| Tg(ctsk:NLS-mCherry) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-113G11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-30O16 | ZFIN Curated Data | |
| Encodes | EST | fa95f03 | Parichy et al., 2000 | |
| Encodes | EST | fb08b05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110367 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191754 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017778 (1) | 1595 nt | ||
| Genomic | GenBank:BX248517 | 201353 nt | ||
| Polypeptide | UniProtKB:Q568D6 (1) | 333 aa |
- Breuer, M., Rummler, M., Singh, J., Maher, S., Zaouter, C., Jamadagni, P., Pilon, N., Willie, B.M., Patten, S.A. (2024) CHD7 regulates craniofacial cartilage development via controlling HTR2B expression. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 39(4):498-512
- Jiang, R.X., Hu, N., Deng, Y.W., Hu, L.W., Gu, H., Luo, N., Wen, J., Jiang, X.Q. (2024) Potential therapeutic role of spermine via Rac1 in osteoporosis: Insights from zebrafish and mice. Zoological research. 45:367380367-380
- Lee, J.J., Wang, T., Wiggins, K., Lu, P.N., Underwood, C., Ochenkowska, K., Samarut, E., Pollard, L.M., Flanagan-Steet, H., Steet, R. (2024) Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders. iScience. 27:109293109293
- Yu, T., Chen, M., Wen, J., Liu, J., Li, K., Jin, L., Yue, J., Yang, Z., Xi, J. (2024) The effects of all-trans retinoic acid on prednisolone-induced osteoporosis in zebrafish larvae. Bone. 189:117261
- Carletti, A., Rosa, J.T., Pes, K., Borges, I., Santos, T., Barreira, L., Varela, J., Pereira, H., Cancela, M.L., Gavaia, P.J., Laizé, V. (2023) The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models. Cellular and molecular life sciences : CMLS. 80:310310
- Guo, W., Jin, P., Li, R., Huang, L., Liu, Z., Li, H., Zhou, T., Fang, B., Xia, L. (2023) Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis. Experimental & molecular medicine. 55(1):81-94
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Seda, M., Crespo, B., Corcelli, M., Osborn, D.P., Jenkins, D. (2023) A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Scientific Reports. 13:67836783
- Tonelli, F., Leoni, L., Daponte, V., Gioia, R., Cotti, S., Fiedler, I.A.K., Larianova, D., Willaert, A., Coucke, P.J., Villani, S., Busse, B., Besio, R., Rossi, A., Witten, P.E., Forlino, A. (2023) Zebrafish Tric-b is required for skeletal development and bone cells differentiation. Frontiers in endocrinology. 14:10029141002914
- Wu, Z., Shi, Y., Cui, Y., Xing, X., Zhang, L., Liu, D., Zhang, Y., Dong, J., Jin, L., Pang, M., Xiao, R.P., Zhu, Z., Xiong, J.W., Tong, X., Zhang, Y., Wang, S., Tang, F., Zhang, B. (2023) Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration. Protein & cell. 14:350368350-368
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