Gene

ctsk

ID

ZDB-GENE-001205-4

Name

cathepsin K

Symbol

ctsk Nomenclature History

Previous Names

etID33526.16 (1)
wu:fa95f03
wu:fb08b05
zgc:110367

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within bone morphogenesis; cartilage development; and response to mechanical stimulus. Predicted to be located in plasma membrane. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including cardiovascular system; fin; head; lateral line system; and mesoderm. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

33 figures from 25 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110367 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctsk Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pycnodysostosis	Alliance	Pycnodysostosis	265800

Associated With ctsk Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR000169	Cysteine peptidase, cysteine active site
Active_site	IPR025660	Cysteine peptidase, histidine active site
Active_site	IPR025661	Cysteine peptidase, asparagine active site
Domain	IPR000668	Peptidase C1A, papain C-terminal
Domain	IPR013201	Cathepsin propeptide inhibitor domain (I29)
Domain	IPR039417	Papain-like cysteine endopeptidase
Family	IPR013128	Peptidase C1A
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily