Gene
atp1b3b
- ID
- ZDB-GENE-001127-1
- Name
- ATPase Na+/K+ transporting subunit beta 3b
- Symbol
- atp1b3b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to act upstream of or within potassium ion transport and sodium ion transport. Predicted to be located in membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including musculature system; nervous system; neural tube; otic vesicle; and polster. Orthologous to human ATP1B3 (ATPase Na+/K+ transporting subunit beta 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb714 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Abu Nahia et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012780Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-atp1b3b | Abu Nahia et al., 2024 | |
| CRISPR2-atp1b3b | Abu Nahia et al., 2024 | |
| CRISPR3-atp1b3b | Abu Nahia et al., 2024 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Sodium/potassium-transporting ATPase subunit beta | Sodium/potassium-transporting ATPase subunit beta superfamily |
|---|---|---|---|---|
| UniProtKB:Q9DGI4 | InterPro | 275 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp1b3b-201
(1)
|
Ensembl | 1,874 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-117A13 | ZFIN Curated Data | |
| Encodes | EST | cb714 | (2) | |
| Encodes | EST | fb13c07 | ZFIN Curated Data | |
| Encodes | EST | fc30g02 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:92524 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131670 (1) | 1755 nt | ||
| Genomic | GenBank:CU467614 (2) | 175198 nt | ||
| Polypeptide | UniProtKB:Q9DGI4 (1) | 275 aa |
- Abu Nahia, K., Sulej, A., Migdał, M., Ochocka, N., Ho, R., Kamińska, B., Zagorski, M., Winata, C.L. (2024) scRNA-seq reveals the diversity of the developing cardiac cell lineage and molecular players in heart rhythm regulation. iScience. 27:110083110083
- Esbaugh, A.J., Brix, K.V., Grosell, M. (2019) Na+ K+ ATPase isoform switching in zebrafish during transition to dilute freshwater habitats. Proceedings. Biological sciences. 286:20190630
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Uusi-Heikkilä, S., Whiteley, A.R., Kuparinen, A., Matsumura, S., Venturelli, P.A., Wolter, C., Slate, J., Primmer, C.R., Meinelt, T., Killen, S.S., Bierbach, D., Polverino, G., Ludwig, A., Arlinghaus, R. (2015) The evolutionary legacy of size-selective harvesting extends from genes to populations. Evolutionary Applications. 8:597-620
- Castro, L.F., Gonçalves, O., Mazan, S., Tay, B.H., Venkatesh, B., Wilson, J.M. (2013) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history. Proceedings. Biological sciences. 281:20132669
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Pujic, Z., Omori, Y., Tsujikawa, M., Thisse, B., Thisse, C., and Malicki, J. (2006) Reverse genetic analysis of neurogenesis in the zebrafish retina. Developmental Biology. 293(2):330-347
- Canfield, V.A., Loppin, B., Thisse, B., Thisse, C., Postlethwait, J.H., Mohideen, A.P.K., Rajarao, S.J.R., and Levenson, R. (2002) Na,K-ATPase alpha and beta subunit genes exhibit unique expression patterns during zebrafish embryogenesis. Mechanisms of Development. 116(1-2):51-59
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