Gene
nos1
- ID
- ZDB-GENE-001101-1
- Name
- nitric oxide synthase 1 (neuronal)
- Symbol
- nos1 Nomenclature History
- Previous Names
-
- nNOS
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable FMN binding activity; flavin adenine dinucleotide binding activity; and nitric-oxide synthase activity. Acts upstream of or within several processes, including hematopoietic stem cell differentiation; nervous system development; and nitric oxide mediated signal transduction. Predicted to be located in dendritic spine and sarcolemma. Predicted to be active in several cellular components, including cytosol; nucleus; and postsynaptic density. Is expressed in several structures, including brain; enteric nervous system; nitrergic neurons; ovary; and spinal cord. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; and cystic fibrosis. Orthologous to human NOS1 (nitric oxide synthase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001094 | Flavodoxin-like |
| Domain | IPR001433 | Oxidoreductase FAD/NAD(P)-binding |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR001709 | Flavoprotein pyridine nucleotide cytochrome reductase |
| Domain | IPR003097 | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding |
| Domain | IPR004030 | Nitric oxide synthase, N-terminal |
| Domain | IPR008254 | Flavodoxin/nitric oxide synthase |
| Domain | IPR017927 | FAD-binding domain, ferredoxin reductase-type |
| Family | IPR012144 | Nitric-oxide synthase, eukaryote |
| Family | IPR050607 | Nitric Oxide Synthase (NOS) |
| Homologous_superfamily | IPR017938 | Riboflavin synthase-like beta-barrel |
| Homologous_superfamily | IPR023173 | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily |
| Homologous_superfamily | IPR029039 | Flavoprotein-like superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036119 | Nitric oxide synthase, N-terminal domain superfamily |
| Homologous_superfamily | IPR039261 | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain |
| Homologous_superfamily | IPR044940 | Nitric oxide synthase, domain 2 superfamily |
| Homologous_superfamily | IPR044943 | Nitric oxide synthase, domain 1 superfamily |
| Homologous_superfamily | IPR044944 | Nitric oxide synthase, domain 3 superfamily |
Domain Details Per Protein
| Protein | Length | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Flavodoxin-like | Flavodoxin/nitric oxide synthase | Flavoprotein-like superfamily | Flavoprotein pyridine nucleotide cytochrome reductase | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily | Nitric oxide synthase, domain 1 superfamily | Nitric oxide synthase, domain 2 superfamily | Nitric oxide synthase, domain 3 superfamily | Nitric-oxide synthase, eukaryote | Nitric Oxide Synthase (NOS) | Nitric oxide synthase, N-terminal | Nitric oxide synthase, N-terminal domain superfamily | Oxidoreductase FAD/NAD(P)-binding | PDZ domain | PDZ superfamily | Riboflavin synthase-like beta-barrel | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q800V0
|
1431 | |||||||||||||||||||
|
UniProtKB:A0A0R4IQG7
|
1431 |
Interactions and Pathways
No data available
Plasmids
No data available