PUBLICATION

Expression of nk2.1a during early development of the thyroid gland in zebrafish

Authors
Rohr, K.B. and Concha, M.L.
ID
ZDB-PUB-000824-17
Date
2000
Source
Mechanisms of Development   95(1-2): 267-270 (Journal)
Registered Authors
Concha, Miguel, Rohr, Klaus
Keywords
thyroid development; TTF-1; nk2.1; Titf-1; fate map; photoactivated fluorescein
MeSH Terms
  • Animals
  • Gene Expression Regulation, Developmental*
  • Homeodomain Proteins/genetics
  • Nuclear Proteins/genetics*
  • Thyroid Gland/embryology*
  • Thyroid Gland/physiology
  • Transcription Factors/genetics*
  • Zebrafish/embryology*
  • Zebrafish/genetics*
PubMed
10906475 Full text @ Mech. Dev.
Abstract
We show here that a zebrafish orthologue of the Thyroid Transcription Factor-1 (TTF-1), nk2.1a, is expressed in the developing thyroid gland. Using a fate mapping approach we found that an early nk2.1a expression domain in the endoderm adjacent to the heart follows morphogenetic movements of the lower jaw, ending up in the region in which the mature thyroid gland is located. We therefore suggest that nk2.1a labels the thyroid precursor cells from somitogenesis stages onwards.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes