PUBLICATION
Expression of nk2.1a during early development of the thyroid gland in zebrafish
- Authors
- Rohr, K.B. and Concha, M.L.
- ID
- ZDB-PUB-000824-17
- Date
- 2000
- Source
- Mechanisms of Development 95(1-2): 267-270 (Journal)
- Registered Authors
- Concha, Miguel, Rohr, Klaus
- Keywords
- thyroid development; TTF-1; nk2.1; Titf-1; fate map; photoactivated fluorescein
- MeSH Terms
-
- Animals
- Gene Expression Regulation, Developmental*
- Homeodomain Proteins/genetics
- Nuclear Proteins/genetics*
- Thyroid Gland/embryology*
- Thyroid Gland/physiology
- Transcription Factors/genetics*
- Zebrafish/embryology*
- Zebrafish/genetics*
- PubMed
- 10906475 Full text @ Mech. Dev.
Citation
Rohr, K.B. and Concha, M.L. (2000) Expression of nk2.1a during early development of the thyroid gland in zebrafish. Mechanisms of Development. 95(1-2):267-270.
Abstract
We show here that a zebrafish orthologue of the Thyroid Transcription Factor-1 (TTF-1), nk2.1a, is expressed in the developing thyroid gland. Using a fate mapping approach we found that an early nk2.1a expression domain in the endoderm adjacent to the heart follows morphogenetic movements of the lower jaw, ending up in the region in which the mature thyroid gland is located. We therefore suggest that nk2.1a labels the thyroid precursor cells from somitogenesis stages onwards.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping