Gene
adar
- ID
- ZDB-GENE-000616-5
- Name
- adenosine deaminase RNA specific
- Symbol
- adar Nomenclature History
- Previous Names
-
- drada
- red1
- wu:fc22a02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to localize to cytoplasm and nucleolus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and dyschromatosis symmetrica hereditaria. Is expressed in brain. Orthologous to human ADAR (adenosine deaminase RNA specific).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu29 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Niescierowicz et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Aicardi-Goutieres syndrome | Alliance | Aicardi-Goutieres syndrome 6 | 615010 |
| dyschromatosis symmetrica hereditaria | Alliance | Dyschromatosis symmetrica hereditaria | 127400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002466 | Adenosine deaminase/editase |
| Domain | IPR014720 | Double-stranded RNA-binding domain |
| Domain | IPR042371 | Z-binding domain |
| Domain | IPR044456 | ADAR1, first double-stranded RNA binding domain |
| Domain | IPR044457 | ADAR1, third double-stranded RNA binding domain |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | ADAR1, first double-stranded RNA binding domain | ADAR1, third double-stranded RNA binding domain | Adenosine deaminase/editase | Double-stranded RNA-binding domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily | Z-binding domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1P8J0
|
1381 |
Interactions and Pathways
No data available
Plasmids
No data available