Gene
badb
- ID
- ZDB-GENE-000616-1
- Name
- BCL2 associated agonist of cell death b
- Symbol
- badb Nomenclature History
- Previous Names
-
- bad
- fa01b12
- proapoptotic BH3-only protein
- wu:fa01b12
- wu:fa96d04
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Acts upstream of or within cellular response to ionizing radiation and positive regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including brain; hindbrain neural plate; immature eye; midbrain hindbrain boundary neural keel; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human BAD (BCL2 associated agonist of cell death).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:114031 (7 images)
- eu145 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Hung et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zd1005 | Allele with one deletion | Unknown | Unknown | TALEN |
1 - 1 of 1
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR018868 | Bcl2-associated agonist of cell death |
Domain Details Per Protein
| Protein | Additional Resources | Length | Bcl2-associated agonist of cell death |
|---|---|---|---|
| UniProtKB:Q9I9N2 | InterPro | 146 | |
| UniProtKB:Q4V925 | InterPro PDB | 147 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(rag2:mCherry-badb) |
|
| 1 | Harrold et al., 2016 | |
| Tg(rag2:mCherry-badb_L99A) |
|
| 1 | Harrold et al., 2016 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001270595 (1) | 1249 nt | ||
| Genomic | GenBank:AL954715 (1) | 195884 nt | ||
| Polypeptide | UniProtKB:Q4V925 (1) | 147 aa |
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
- Da'as, S.I., Ahmed, I., Hasan, W.H., Abdelrahman, D.A., Aliyev, E., Nisar, S., Bhat, A.A., Joglekar, M.V., Hardikar, A.A., Fakhro, K.A., Akil, A.S.A. (2023) The link between glycemic control measures and eye microvascular complications in a clinical cohort of type 2 diabetes with microRNA-223-3p signature. Journal of translational medicine. 21:171171
- Morgan, K.J., Doggett, K., Geng, F., Mieruszynski, S., Whitehead, L., Smith, K.A., Hogan, B.M., Simons, C., Baillie, G.J., Molania, R., Papenfuss, A.T., Hall, T.E., Ober, E.A., Stainier, D.Y.R., Gong, Z., Heath, J.K. (2023) ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma. eLIFE. 12:
- Ahn, J.C., Hwang, S.J., Lee, H.J., Kim, K.W. (2021) Claudin-5a knockdown attenuates blood-neural barrier in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 250:109176
- Hung, J.C., Wu, J.L., Hong, J.R. (2021) Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish. International Journal of Molecular Sciences. 22(9):
- Hung, J.C., Wu, J.L., Li, H.C., Chiu, H.W., Hong, J.R. (2021) The Proapoptotic Gene Bad Regulates Brain Development via p53-Mediated Stress Signals in Zebrafish. Cells. 10(11):
- Wang, J., Thomas, H.R., Li, Z., Yeo, N.C.F., Scott, H.E., Dang, N., Hossain, M.I., Andrabi, S.A., Parant, J.M. (2021) Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis. Cell Death & Disease. 12:659
- Wu, S.Y., Yang, W.Y., Cheng, C.C., Hsiao, M.C., Tsai, S.L., Lin, H.K., Lin, K.H., Yuh, C.H. (2020) Low Molecular Weight Fucoidan Prevents Radiation-Induced Fibrosis and Secondary Tumors in a Zebrafish Model. Cancers. 12(6):
- Wu, Y., Xia, Y., Li, P., Qu, H.Q., Liu, Y., Yang, Y., Lin, J., Zheng, M., Tian, L., Wu, Z., Huang, S., Qin, X., Zhou, X., Chen, S., Liu, Y., Wang, Y., Li, X., Zeng, H., Hakonarson, H., Zhuang, J. (2020) Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome. Orphanet journal of rare diseases. 15:101
- Chen, M., Luo, Y., Xu, J., Chang, M.X., Liu, J.X. (2019) Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival. Frontiers in immunology. 10:2599
1 - 10 of 42
Show