Gene

bdnf

ID

ZDB-GENE-000412-1

Name

brain-derived neurotrophic factor

Symbol

bdnf Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have growth factor activity and nerve growth factor receptor binding activity. Involved in multicellular organismal response to stress and nervous system development. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including blastoderm; digestive system; nervous system; oral region; and pericardial region. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

59 figures from 24 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

MGC:76834 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bdnf Human Ortholog

No data available

Associated With bdnf Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019846	Nerve growth factor conserved site
Domain	IPR002072	Nerve growth factor-related
Family	IPR020408	Nerve growth factor-like
Family	IPR020430	Brain-derived neurotrophic factor
Homologous_superfamily	IPR029034	Cystine-knot cytokine

Domain Details Per Protein

Protein	Length	Brain-derived neurotrophic factor	Cystine-knot cytokine	Nerve growth factor conserved site	Nerve growth factor-like	Nerve growth factor-related
UniProtKB:Q9YH42 InterPro	270
UniProtKB:E9QIT5 InterPro	184
UniProtKB:F1Q5K0 InterPro	143
UniProtKB:B0V301 InterPro	239
UniProtKB:C5IG38 InterPro	232
UniProtKB:Q6NZ01 InterPro	270

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	bdnf-201 (1) Ensembl	1866 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	bdnf-202 (1) Ensembl	1100 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	bdnf-203 (1) Ensembl	1446 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	bdnf-204 (1) Ensembl	857 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	bdnf-205 (1) Ensembl	869 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-bdnf	polyclonal	bdnf		Rabbit	IHC WB	Millipore	8

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations