ZFIN Gene: bdnf

ZFIN ID: ZDB-GENE-000412-1

ZFIN ID: ZDB-GENE-000412-1

Gene Name:

brain-derived neurotrophic factor

Gene Symbol:

bdnf Nomenclature History

Previous Name:

Gene Type:

protein_coding_gene

Location:

Chr: 7 Mapping Details/Browsers

Description:

Predicted to have growth factor activity and nerve growth factor receptor binding activity. Involved in multicellular organismal response to stress and nervous system development. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including blastoderm; digestive system; nervous system; oral region; and pericardial region. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor).

Genome Resources:

Alliance (1), Gene:58118 (1), Ensembl(GRCz11):ENSDARG00000018817 (2)

GENE EXPRESSION
All Expression Data:	55 figures from 21 publications
Directly Submitted Expression Data:	6 figures (18 images) from Rauch et al., 2003 [MGC:65746]
	6 figures (7 images) from Thisse et al., 2004 [MGC:76834]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
	blastomere brain caudal fin caudal tuberculum central nervous system cerebellum cloaca cranial ganglion cranial nerve DEL diencephalon dorsal telencephalon EVL eye forebrain gill gut neuroendocrine cell heart heart tube hindbrain hindbrain neural plate hypophysis hypothalamus neuron hypothalamus inner ear hair cell inner ear integument intestine lateral line lateral line primordium lateral line system liver medulla oblongata midbrain musculature system neural rod neural tube neuromast neuromast hair cell neuron olfactory bulb olfactory epithelium olfactory pit olfactory placode optic cup optic tectum optic vesicle oral epithelium otic placode otic vesicle pectoral fin periderm peripheral olfactory organ pharyngeal arch 3-7 pharyngeal epithelium preoptic area pretectum primitive olfactory epithelium retina retinal ganglion cell layer retinal inner nuclear layer rhombomere somite spinal cord ventro-lateral margin spinal cord tegmentum telencephalon ventral mandibular arch ventral thalamus whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa34104	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-bdnf	N/A	4
MO2-bdnf	N/A	1

PHENOTYPE

Data:	4 figures from 4 publications
Observed in:	activation of cysteine-type endopeptidase activity involved in apoptotic process cranial nerve II eye head locomotion motor neuron neuron projection pericardium swim bladder ventral mandibular arch ventricular system whole organism

DISEASE ASSOCIATED WITH bdnf HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH bdnf VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	presynapse assembly (more)
Cellular Component	axon (more)
Molecular Function	growth factor activity (more)

GO Terms (all 23)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	bdnf-201 (1)	1866	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	bdnf-202 (1)	1100	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	bdnf-203 (1)	1446	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	bdnf-204 (1)	857	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	bdnf-205 (1)	869	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Source	Publications
Ab1-bdnf	polyclonal		Rabbit	IHC, WB	Millipore	6

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM bdnf No data available

MARKER RELATIONSHIPS

bdnf Contained in:	[BAC] CH73-387L4 (1), CH211-214A19 (1), CH211-251J8 (1)
bdnf Encodes:	[cDNA] MGC:65746 (1), MGC:76834 (1), MGC:76835 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131595 (1)	1904 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL935207 (1)	146351 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q6NZ01 (1)	270 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 33)

ORTHOLOGY for bdnf ( Chr: 7 )

CITATIONS (117)

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