| ZFIN ID: ZDB-GENE-000329-3 |
| Gene Name: | actin, beta 2 | |||||||||||||
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| Gene Symbol: | actb2 Nomenclature History |
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Attributions
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| Previous Names: | bact2, bactin2 (1), fa56g06, fb38a10, wu:fa56g06 (1), wu:fb38a10 (1) | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 3 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to localize to several cellular components, including actin filament; dense body; and focal adhesion. Is expressed in several structures, including blastomere; brain; eye; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome and autosomal dominant nonsyndromic deafness 20. Orthologous to several human genes including ACTB (actin beta). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:57935 (1), Ensembl(GRCz11):ENSDARG00000037870 (2) | |||||||||||||
| All Expression Data: | 21 figures from 16 publications |
| Directly Submitted Expression Data: | 1 figure (1 image) from Thisse et al., 2004 [MGC:56040] |
| Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult) |
| High Throughput Expression: | GEO (1) , Expression Atlas (1) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| sa45150 | Point Mutation | Unknown | Premature Stop | ENU |
|
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Baraitser-Winter syndrome | Alliance | Baraitser-Winter syndrome 1 | 243310 |
| ?Dystonia, juvenile-onset | 607371 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Cellular Component | cytoskeleton (more) |
| Molecular Function | ATP binding (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| aberrant processed transcript |
actb2-207
(1)
|
1118 |
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| mRNA |
actb2-201
(1)
|
1762 |
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actb2-206
(1)
|
1789 |
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| ncRNA |
actb2-003
(1)
|
730 |
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actb2-004
(1)
|
857 |
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actb2-005
(1)
|
867 |
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actb2-006
(1)
|
842 |
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM actb2
MARKER RELATIONSHIPS
| actb2 Contained in: | [BAC] CH211-255L18 (1) |
| actb2 Encodes: |
[EST]
fa56g06 (1),
fb38a10 (1),
fj16d08
[cDNA] MGC:56040 (1), MGC:85665 (1), MGC:172104 (1), MGC:192911 (1) |
| actb2 Has Artifact: | [EST] fb12f11 |
| actb2 Is Hybridized by: | [EST] fj81g03 |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_181601 (1) | 1786 nt |
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| Genomic | GenBank:AL929031 (1) | 187548 nt | |
| Polypeptide | UniProtKB:A8WG05 (1) | 375 aa |
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ORTHOLOGY for actb2 (
Chr:
3
)
CITATIONS (265)