Gene
tbr1b
- ID
- ZDB-GENE-000323-1
- Name
- T-box brain transcription factor 1b
- Symbol
- tbr1b Nomenclature History
- Previous Names
-
- tbr1
- zf-tbr1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including commitment of neuronal cell to specific neuron type in forebrain; regulation of neuron projection development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in margin; nervous system; and shield. Orthologous to human TBR1 (T-box brain transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu258 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb24 | Allele with one deletion | Unknown | Unknown | TALEN | |
| ihb26 | Allele with one deletion | Unknown | Unknown | TALEN | |
| mpn409Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa10845 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34772 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41554 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| ya508 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| ya532 | Allele with multiple variants | Unknown | Unknown | CRISPR |
1 - 8 of 8
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tbr1b | Kölsch et al., 2020 | |
| CRISPR2-tbr1b | (2) | |
| CRISPR3-tbr1b | (2) |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder with autism and speech delay | 606053 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR032385 | T-box transcription factor-associated |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor-associated | T-box transcription factor, DNA-binding domain | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B5DE34 | InterPro | 676 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(tbr1:EYFP) |
|
| 2 | (6) |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-192A6 | ZFIN Curated Data | |
| Encodes | EST | eu258 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:175170 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001115090 (1) | 3855 nt | ||
| Genomic | GenBank:CU651665 (2) | 37255 nt | ||
| Polypeptide | UniProtKB:B5DE34 (1) | 676 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Umeda, K., Tanaka, K., Chowdhury, G., Nasu, K., Kuroyanagi, Y., Yamasu, K. (2024) Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos. Development, growth & differentiation. 66(3):219-234
- Shainer, I., Kuehn, E., Laurell, E., Al Kassar, M., Mokayes, N., Sherman, S., Larsch, J., Kunst, M., Baier, H. (2023) A single-cell resolution gene expression atlas of the larval zebrafish brain. Science advances. 9:eade9909
- Weinschutz Mendes, H., Neelakantan, U., Liu, Y., Fitzpatrick, S.E., Chen, T., Wu, W., Pruitt, A., Jin, D.S., Jamadagni, P., Carlson, M., Lacadie, C.M., Enriquez, K.D., Li, N., Zhao, D., Ijaz, S., Sakai, C., Szi, C., Rooney, B., Ghosh, M., Nwabudike, I., Gorodezky, A., Chowdhury, S., Zaheer, M., McLaughlin, S., Fernandez, J.M., Wu, J., Eilbott, J.A., Vander Wyk, B., Rihel, J., Papademetris, X., Wang, Z., Hoffman, E.J. (2023) High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways. Cell Reports. 42:112243112243
- Talbot, C.D., Walsh, M.D., Cutty, S.J., Elsayed, R., Vlachaki, E., Bruce, A.E.E., Wardle, F.C., Nelson, A.C. (2022) Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops. Frontiers in cell and developmental biology. 10:982477
- Turner, K.J., Hawkins, T.A., Henriques, P.M., Valdivia, L.E., Bianco, I.H., Wilson, S.W., Folgueira, M. (2022) A Structural Atlas of the Developing Zebrafish Telencephalon Based on Spatially-Restricted Transgene Expression. Frontiers in Neuroanatomy. 16:840924
- Zhu, J., Li, X., Sun, X., Zhou, Z., Cai, X., Liu, X., Wang, J., Xiao, W. (2021) Zebrafish prmt2 Attenuates Antiviral Innate Immunity by Targeting traf6. Journal of immunology (Baltimore, Md. : 1950). 207(10):2570-2580
- Kölsch, Y., Hahn, J., Sappington, A., Stemmer, M., Fernandes, A.M., Helmbrecht, T.O., Lele, S., Butrus, S., Laurell, E., Arnold-Ammer, I., Shekhar, K., Sanes, J.R., Baier, H. (2020) Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior. Neuron. 109(4):645-662.e9
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Chen, W., Bian, C., You, X., Li, J., Ye, L., Wen, Z., Lv, Y., Zhang, X., Xu, J., Yang, S., Gu, R., Lin, X., Shi, Q. (2019) Genome Sequencing of the Japanese Eel (Anguilla japonica) for Comparative Genomic Studies on tbx4 and a tbx4 Gene Cluster in Teleost Fishes. Marine drugs. 17(7)
1 - 10 of 44
Show