Gene

tbr1b

ID
ZDB-GENE-000323-1
Name
T-box brain transcription factor 1b
Symbol
tbr1b Nomenclature History
Previous Names
  • tbr1
  • zf-tbr1 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including generation of neurons; heart looping; and regulation of transcription by RNA polymerase II. Predicted to localize to nuclear chromatin. Is expressed in nervous system and shield. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TBR1 (T-box brain transcription factor 1).
Genome Resources
Note
None
Expression
All Expression Data
21 figures from 14 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbr1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Intellectual developmental disorder with autism and speech delay 606053
Associated With tbr1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018186 Transcription factor, T-box, conserved site
Domain IPR032385 T-box transcription factor-associated
Family IPR001699 Transcription factor, T-box
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR036960 T-box superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding T-box superfamily T-box transcription factor-associated Transcription factor, T-box Transcription factor, T-box, conserved site
UniProtKB:A4KUL8 215
UniProtKB:B5DE34 676
UniProtKB:Q9DDU4 437
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations