Gene

tbr1b

ID

ZDB-GENE-000323-1

Name

T-box brain transcription factor 1b

Symbol

tbr1b Nomenclature History

Previous Names

tbr1
zf-tbr1 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including commitment of neuronal cell to specific neuron type in forebrain; regulation of neuron projection development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in margin; nervous system; and shield. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TBR1 (T-box brain transcription factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

23 figures from 16 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu258 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tbr1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder with autism and speech delay	606053

Associated With tbr1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018186	Transcription factor, T-box, conserved site
Domain	IPR032385	T-box transcription factor-associated
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding
Homologous_superfamily	IPR036960	T-box superfamily