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ZIRC
ZFIN ID: ZDB-GENE-000209-4
Gene Name: roundabout, axon guidance receptor, homolog 3 (Drosophila)
Gene Symbol: robo3    Nomenclature History

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Previous Names: cb503 (1), twi, twitch twice (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have cell-cell adhesion mediator activity. Involved in axonogenesis and determination of ventral identity. Localizes to the integral component of plasma membrane. Is expressed in several structures, including EVL; digestive system; fin; nervous system; and neural tube. Orthologous to human ROBO3 (roundabout guidance receptor 3).
Genome Resources: Alliance (1),  Gene:30770 (1),  Ensembl(GRCz11):ENSDARG00000005645 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027172Tg Transgenic Insertion Unknown Unknown DNA
sa13775 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tg224a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tw204 Complex Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tx209 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-robo3 N/A 2
    MO2-robo3 N/A 1
    MO3-robo3 N/A 1
    MO4-robo3 N/A 1
    MO5-robo3 N/A 2
    DISEASE ASSOCIATED WITH robo3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Gaze palsy, familial horizontal, with progressive scoliosis, 1 607313
    DISEASE ASSOCIATED WITH robo3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon guidance (more)
    Cellular Component integral component of plasma membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 14)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA robo3-201 (1)    Ensembl 5056
    robo3-202 (1)    Ensembl 5344
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM robo3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:robo3-001,EGFP) hsp70l EGFProbo3robo3-202 Danio rerio 1 2
    Tg(hsp70l:robo3-002,EGFP) hsp70l EGFProbo3robo3-201 Danio rerio 1 2
    Tg(hsp70l:robo3-2A-Tomato-CAAX) hsp70l 2ACAAXrobo3Tomato Danio rerio 1 1
    Tg(hsp70l:robo3_L125P-2A-Tomato-CAAX) hsp70l 2ACAAXrobo3Tomato Danio rerio 1 1
    Tg(hsp70l:robo3_N83P_K85R-2A-Tomato-CAAX) hsp70l 2ACAAXrobo3Tomato Danio rerio 1 1
    MARKER RELATIONSHIPS
    robo3 Contained in: [BAC] DKEY-30J19 (1) (order this), DKEY-77G18 (1) (order this), DKEY-119J14 (1) (order this)
    robo3 Encodes: [EST] cb503 (1) (order this), fb78e10
    [cDNA] cssl:d102 (1) (order this), MGC:194799 (1) (order this), MGC:194810 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131482 (1) 5384 bp
    Genomic GenBank:AL845320 (1) 183417 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QRK0 (1) 1420 aa
    Sequence Clusters UniGene:77473 (1)
    Sequence Information (all 48)
    ORTHOLOGY for robo3 ( Chr: 10 )
    CITATIONS (56)