Gene
copg2
- ID
- ZDB-GENE-000208-8
- Name
- COPI coat complex subunit gamma 2
- Symbol
- copg2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Predicted to be involved in Golgi vesicle transport; organelle transport along microtubule; and protein secretion. Predicted to act upstream of or within intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and membrane. Predicted to be part of COPI vesicle coat. Predicted to be active in Golgi membrane; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including axis; notochord; periderm; polster; and solid lens vesicle. Human ortholog(s) of this gene implicated in immunodeficiency 128. Orthologous to several human genes including COPG2 (COPI coat complex subunit gamma 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56111 (1 image)
- cb943 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa30609 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa30848 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33433 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40262 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 4 of 4
Show
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002553 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| Domain | IPR013040 | Coatomer, gamma subunit, appendage, Ig-like subdomain |
| Domain | IPR032154 | Coatomer subunit gamma, C-terminal |
| Family | IPR017106 | Coatomer gamma subunit |
| Homologous_superfamily | IPR009028 | Coatomer/calthrin adaptor appendage, C-terminal subdomain |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR012295 | TBP domain superfamily |
| Homologous_superfamily | IPR013041 | Clathrin adaptor, appendage, Ig-like subdomain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR037067 | Coatomer, gamma subunit, appendage domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Clathrin adaptor, appendage, Ig-like subdomain superfamily | Clathrin/coatomer adaptor, adaptin-like, N-terminal | Coatomer/calthrin adaptor appendage, C-terminal subdomain | Coatomer gamma subunit | Coatomer, gamma subunit, appendage domain superfamily | Coatomer, gamma subunit, appendage, Ig-like subdomain | Coatomer subunit gamma, C-terminal | TBP domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9PUE4 | InterPro | 873 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-285D14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-117N7 | ZFIN Curated Data | |
| Encodes | EST | cb943 | Thisse et al., 2001 | |
| Encodes | EST | fi31b06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56111 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111940 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193067 | ZFIN Curated Data |
1 - 7 of 7
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130994 (1) | 2893 nt | ||
| Genomic | GenBank:BX004864 (1) | 153799 nt | ||
| Polypeptide | UniProtKB:Q9PUE4 (1) | 873 aa |
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Beaudoin, J.D., Novoa, E.M., Vejnar, C.E., Yartseva, V., Takacs, C.M., Kellis, M., Giraldez, A.J. (2018) Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Nature structural & molecular biology. 25(8):677-686
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Chen, J., Wu, X., Yao, L., Yan, L., Zhang, L., Qiu, J., Liu, X., Jia, S., Meng, A. (2017) Impairment of Cargo Transportation Caused by gbf1 Mutation Disrupts Vascular Integrity and Causes Hemorrhage in Zebrafish Embryos.. The Journal of biological chemistry. 292(6):2315-2327
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hahn, Y., Yang, S.K., and Chung, J.H. (2005) Structure and expression of the zebrafish mest gene, an ortholog of mammalian imprinted gene PEG1/MEST. BBA Gene Structure and Expression. 1731(2):125-132
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Hahn, Y., Lee, Y.J., Yun, J.H., Yang, S.K., Park, C.W., Mita, K., Huh, T., Rhee, M., and Chung, J.H. (2000) Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution. FEBS letters. 482(1-2):31-36
1 - 8 of 8
Show