Gene

zic1

ID
ZDB-GENE-000208-4
Name
zic family member 1 (odd-paired homolog, Drosophila)
Symbol
zic1 Nomenclature History
Previous Names
  • odd-paired-like (1)
  • opl (1)
  • wu:fj51c06 (1)
  • zgc:136736
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Involved in brain development and embryonic retina morphogenesis in camera-type eye. Predicted to localize to nucleus. Is expressed in several structures, including central nervous system; neural keel; neural plate; neural rod; and presumptive neural plate. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome and craniosynostosis. Orthologous to human ZIC1 (Zic family member 1).
Genome Resources
Note
None
Expression
All Expression Data
70 figures from 43 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from Maurus et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zic1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Structural brain anomalies with impaired intellectual development and craniosynostosis 618736
?Craniosynostosis 6 616602
Associated With zic1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Domain IPR041643 ZIC protein, zinc finger domain
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length ZIC protein, zinc finger domain Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:A4KUG6 285
UniProtKB:O93311 442
UniProtKB:Q9PVD6 183
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations