Gene
zic1
- ID
- ZDB-GENE-000208-4
- Name
- zic family member 1 (odd-paired homolog, Drosophila)
- Symbol
- zic1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Acts upstream of or within brain development and embryonic retina morphogenesis in camera-type eye. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; neural keel; neural plate; neural rod; and presumptive neural plate. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome and craniosynostosis 6. Orthologous to human ZIC1 (Zic family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 74 figures from 46 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76803 (26 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-zic1 | (2) | |
| CRISPR2-zic1 | (3) | |
| CRISPR3-zic1 | (2) | |
| CRISPR4-zic1 | (2) | |
| CRISPR5-zic1 | (2) | |
| CRISPR6-zic1 | (2) | |
| CRISPR7-zic1 | (2) | |
| CRISPR8-zic1 | (2) | |
| CRISPR9-zic1 | Medina-Gomez et al., 2023 | |
| CRISPR10-zic1 | Medina-Gomez et al., 2023 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| craniosynostosis 6 | Alliance | ?Craniosynostosis 6 | 616602 |
| Structural brain anomalies with impaired intellectual development and craniosynostosis | 618736 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C2H2-type zinc-finger protein GLI-like | ZIC protein, zinc finger domain | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|
| UniProtKB:O93311 | InterPro | 442 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-95F4 | ZFIN Curated Data | |
| Encodes | EST | cegs2525 | Rauch et al., 2003 | |
| Encodes | EST | fj51c06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76803 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136736 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130933 (1) | 2509 nt | ||
| Genomic | GenBank:CR388127 (2) | 38958 nt | ||
| Polypeptide | UniProtKB:O93311 (1) | 442 aa |
- Carroll, S.H., Schafer, S., Kawasaki, K., Tsimbal, C., Jule, A.M., Hallett, S.A., Li, E., Liao, E.C. (2024) Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis. eLIFE. 13:
- Umeda, K., Tanaka, K., Chowdhury, G., Nasu, K., Kuroyanagi, Y., Yamasu, K. (2024) Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos. Development, growth & differentiation. 66(3):219-234
- Medina-Gomez, C., Mullin, B.H., Chesi, A., Prijatelj, V., Kemp, J.P., Shochat-Carvalho, C., Trajanoska, K., Wang, C., Joro, R., Evans, T.E., Schraut, K.E., Li-Gao, R., Ahluwalia, T.S., Zillikens, M.C., Zhu, K., Mook-Kanamori, D.O., Evans, D.S., Nethander, M., Knol, M.J., Thorleifsson, G., Prokic, I., Zemel, B., Broer, L., McGuigan, F.E., van Schoor, N.M., Reppe, S., Pawlak, M.A., Ralston, S.H., van der Velde, N., Lorentzon, M., Stefansson, K., Adams, H.H.H., Wilson, S.G., Ikram, M.A., Walsh, J.P., Lakka, T.A., Gautvik, K.M., Wilson, J.F., Orwoll, E.S., van Duijn, C.M., Bønnelykke, K., Uitterlinden, A.G., Styrkársdóttir, U., Akesson, K.E., Spector, T.D., Tobias, J.H., Ohlsson, C., Felix, J.F., Bisgaard, H., Grant, S.F.A., Richards, J.B., Evans, D.M., van der Eerden, B., van de Peppel, J., Ackert-Bicknell, C., Karasik, D., Kague, E., Rivadeneira, F. (2023) Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis. Communications biology. 6:691691
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Pradhan, S.J., Reddy, P.C., Smutny, M., Sharma, A., Sako, K., Oak, M.S., Shah, R., Pal, M., Deshpande, O., Dsilva, G., Tang, Y., Mishra, R., Deshpande, G., Giraldez, A.J., Sonawane, M., Heisenberg, C.P., Galande, S. (2021) Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Nature communications. 12:6094
- Wang, B., Rong, X., Zhou, Y., Liu, Y., Sun, J., Zhao, B., Deng, B., Lu, L., Lu, L., Li, Y., Zhou, J. (2021) Eukaryotic initiation factor 4A3 inhibits Wnt/β-catenin signaling and regulates axis formation in zebrafish embryos. Development (Cambridge, England). 148(9):
- Green, D.G., Whitener, A.E., Mohanty, S., Mistretta, B., Gunaratne, P., Yeh, A.T., Lekven, A.C. (2020) Wnt signaling regulates neural plate patterning in distinct temporal phases with dynamic transcriptional outputs. Developmental Biology. 462(2):152-164
- Zhu, J., Wang, H.T., Chen, Y.R., Yan, L.Y., Han, Y.Y., Liu, L.Y., Cao, Y., Liu, Z.Z., Xu, H.A. (2020) The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish. Neuroscience Bulletin. 36(9):1023-1034
- Cosacak, M.I., Bhattarai, P., Reinhardt, S., Petzold, A., Dahl, A., Zhang, Y., Kizil, C. (2019) Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity. Cell Reports. 27:1307-1318.e3
- Lazcano, I., Rodríguez-Ortiz, R., Villalobos, P., Martínez-Torres, A., Solís-Saínz, J.C., Orozco, A. (2019) Knock-Down of Specific Thyroid Hormone Receptor Isoforms Impairs Body Plan Development in Zebrafish. Frontiers in endocrinology. 10:156
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