Gene

zic1

ID

ZDB-GENE-000208-4

Name

zic family member 1 (odd-paired homolog, Drosophila)

Symbol

zic1 Nomenclature History

Previous Names

odd-paired-like (1)
opl (1)
wu:fj51c06 (1)
zgc:136736

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Involved in brain development and embryonic retina morphogenesis in camera-type eye. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome and craniosynostosis. Is expressed in several structures, including central nervous system; neural keel; neural plate; neural rod; and presumptive neural plate. Orthologous to human ZIC1 (Zic family member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

73 figures from 45 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:76803 (26 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zic1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Structural brain anomalies with impaired intellectual development and craniosynostosis	618736
		?Craniosynostosis 6	616602

Associated With zic1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Domain	IPR041643	ZIC protein, zinc finger domain
Family	IPR050329	GLI C2H2-type zinc-finger
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily