Gene

zic1

ID
ZDB-GENE-000208-4
Name
zic family member 1 (odd-paired homolog, Drosophila)
Symbol
zic1 Nomenclature History
Previous Names
  • odd-paired-like (1)
  • opl (1)
  • wu:fj51c06 (1)
  • zgc:136736
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Acts upstream of or within brain development and embryonic retina morphogenesis in camera-type eye. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; neural keel; neural plate; neural rod; and presumptive neural plate. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome and craniosynostosis. Orthologous to human ZIC1 (Zic family member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
71 figures from 44 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from Maurus et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zic1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Structural brain anomalies with impaired intellectual development and craniosynostosis 618736
?Craniosynostosis 6 616602
Associated With zic1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Domain IPR041643 ZIC protein, zinc finger domain
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length ZIC protein, zinc finger domain Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:O93311 442
UniProtKB:A4KUG6 285
UniProtKB:Q9PVD6 183
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations