ZFIN ID: ZDB-GENE-000208-4 |
Gene Name: | zic family member 1 (odd-paired homolog, Drosophila) | ||||||
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Gene Symbol: | zic1 Nomenclature History | ||||||
Previous Names: | odd-paired-like (1), opl (1), wu:fj51c06 (1), zgc:136736 | ||||||
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Gene Type: | protein_coding_gene | ||||||
Location: | Chr: 24 Mapping Details/Browsers | ||||||
Description: | Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Involved in brain development and embryonic retina morphogenesis in camera-type eye. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome and craniosynostosis. Is expressed in several structures, including central nervous system; neural keel; neural plate; neural rod; and presumptive neural plate. Orthologous to human ZIC1 (Zic family member 1). | ||||||
Genome Resources: | Alliance (1), Gene:30096 (1), Ensembl(GRCz11):ENSDARG00000015567 (2) |
Allele | Type | Localization | Consequence | Mutagen | Suppliers |
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sa5987 | Point Mutation | Unknown | Splice Site | ENU | |
sa12532 | Point Mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Publications |
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CRISPR1-zic1 |
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2 |
CRISPR2-zic1 |
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2 |
CRISPR3-zic1 |
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2 |
CRISPR4-zic1 |
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2 |
CRISPR5-zic1 |
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2 |
CRISPR6-zic1 |
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2 |
CRISPR7-zic1 |
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2 |
CRISPR8-zic1 |
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2 |
MO1-zic1 | N/A | 1 |
MO2-zic1 | N/A | 1 |
MO3-zic1 | N/A | 1 |
MO4-zic1 | N/A | 1 |
Data: | 7 figures from Maurus et al., 2009 |
Observed in: |
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
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Craniosynostosis 6 | 616602 |
Ontology | GO Term |
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Biological Process | cell proliferation in hindbrain (more) |
Cellular Component | nucleus (more) |
Molecular Function | zinc ion binding (more) |
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Type | Name | Length (nt) | Analysis | |
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mRNA |
zic1-201
(1)
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2262 |
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Browsers: UCSC, NCBI, Ensembl, ZFIN |
zic1 Contained in: | [BAC] CH211-95F4 (1) (order this) |
zic1 Encodes: |
[EST]
cegs2525 (1) (order this),
fj51c06 (1)
[cDNA] MGC:76803 (1) (order this), MGC:136736 (1) (order this) |
Type | Accession # | Length (bp/aa) | Analysis |
---|---|---|---|
RNA | RefSeq:NM_130933 (1) | 2260 bp |
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Genomic | GenBank:CR388127 (1) | 38958 bp | |
Polypeptide | UniProtKB:O93311 (1) | 442 aa |
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Sequence Clusters | UniGene:75836 (1) |