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ZIRC
ZFIN ID: ZDB-GENE-000208-4
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Gene Name: zic family member 1 (odd-paired homolog, Drosophila)
Gene Symbol: zic1    Nomenclature History

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Previous Names: odd-paired-like (1), opl (1), wu:fj51c06 (1), zgc:136736

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Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Involved in brain development and embryonic retina morphogenesis in camera-type eye. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome and craniosynostosis. Is expressed in several structures, including central nervous system; neural keel; neural plate; neural rod; and presumptive neural plate. Orthologous to human ZIC1 (Zic family member 1).
Genome Resources: Alliance (1),  Gene:30096 (1),  Ensembl(GRCz11):ENSDARG00000015567 (2)
GENE EXPRESSION
All Expression Data: 69 figures from 42 publications
Directly Submitted Expression Data: 7 figures (26 images) from Thisse et al., 2004 [MGC:76803]
  7 figures (34 images) from Rauch et al., 2003 [cegs2525]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa5987 Point Mutation Unknown Splice Site ENU
sa12532 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-zic1
    		2
    CRISPR2-zic1
    		2
    CRISPR3-zic1
    		2
    CRISPR4-zic1
    		2
    CRISPR5-zic1
    		2
    CRISPR6-zic1
    		2
    CRISPR7-zic1
    		2
    CRISPR8-zic1
    		2
    MO1-zic1 N/A 1
    MO2-zic1 N/A 1
    MO3-zic1 N/A 1
    MO4-zic1 N/A 1
    PHENOTYPE
    Data: 7 figures from Maurus et al., 2009
    Observed in:
    DISEASE ASSOCIATED WITH zic1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Craniosynostosis 6 616602
    DISEASE ASSOCIATED WITH zic1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell proliferation in hindbrain (more)
    Cellular Component nucleus (more)
    Molecular Function zinc ion binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR013087 (1)
  • InterPro:IPR036236 (1)
  • InterPro:IPR041643 (1)
  • PROSITE:PS00028 (1)
  • PROSITE:PS50157 (1)
  • Pfam:PF00096 (1)
  • Pfam:PF18366 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA zic1-201 (1)    Ensembl 2262
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM zic1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Et(zic4:GAL4TA4,UAS:mCherry) zic1,  zic4 GAL4TA4,  mCherry Danio rerio 1 7
    Tg(zic1:GAL4-VP16) zic1 GAL4,  VP16 Danio rerio 1 3
    MARKER RELATIONSHIPS
    zic1 Contained in: [BAC] CH211-95F4 (1) (order this)
    zic1 Encodes: [EST] cegs2525 (1) (order this), fj51c06 (1)
    [cDNA] MGC:76803 (1) (order this), MGC:136736 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130933 (1) 2260 bp
    Select Tool
    Genomic GenBank:CR388127 (1) 38958 bp
    Select Tool
    Polypeptide UniProtKB:O93311 (1) 442 aa
    Select Tool
    Sequence Clusters UniGene:75836 (1)
    Sequence Information (all 21)
    ORTHOLOGY for zic1 ( Chr: 24 )
    CITATIONS (91)