Gene

anos1b

ID

ZDB-GENE-000201-13

Name

anosmin 1b

Symbol

anos1b Nomenclature History

Previous Names

anosmin-1b (1)
kal1b
kal1.2

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have peptidase inhibitor activity. Involved in posterior lateral line neuromast deposition. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 1 with or without anosmia. Is expressed in several structures, including brain; hair cell; sensory system; tail bud; and vertical myoseptum. Orthologous to human ANOS1 (anosmin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With anos1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypogonadotropic hypogonadism 1 with or without anosmia	Alliance	Hypogonadotropic hypogonadism 1 with or without anosmia (Kallmann syndrome 1)	308700

Associated With anos1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003961	Fibronectin type III
Domain	IPR008197	WAP-type 'four-disulfide core' domain
Domain	IPR040957	Anosmin-1, cysteine rich domain
Family	IPR042447	Anosmin-1
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036645	Elafin-like superfamily