FIGURE

Fig 2

ID

ZDB-FIG-261014-380

Publication

Saurav et al., 2026 - IP3R2-mediated inter-organelle calcium signaling suppresses melanosome degradation

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Fig 2

IP₃R2 drives pigmentation in vivo.
(A) qRT-PCR analysis showing decrease in IP₃R2 mRNA expression after 48 h post fertilization (hpf) on zebrafish larvae injected with 400 μM IP₃R2 morpholino (N = 3). (B) Representative images of Assam wild type (ASWT) zebrafish after 48hpf injected with 400 μM IP₃R2 morpholino. (C) Bar graph showing melanin content estimation of zebrafish after 48hpf injected with 400 μM IP₃R2 morpholino (N = 3 with 20 embryos in each “N”). (D) qRT-PCR analysis showing increase in IP₃R2 mRNA expression after 48hpf on zebrafish larvae injected with 400 μM IP₃R2 morpholino and rescued with 120 ng of IP₃R2 mRNA (N = 4). (E) Representative images of ASWT zebrafish embryos after 48hpf injected with 400 μM IP₃R2 morpholino and rescued with 120 ng of IP₃R2 mRNA. (F) Bar graph showing melanin content estimation of zebrafish embryos after 48hpf injected with 400 μM IP₃R2 morpholino and rescued with 120 ng of IP₃R2 mRNA (N = 3 with 20 embryos in each “N”). Data presented are mean ± SEM. For statistical analysis, one-sample t test was performed for panels A, C, D, F using GraphPad Prism software. Here, * p < 0.05, ** p < 0.01 and **** p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-itpr2
Knockdown Reagent:	MO1-itpr2
Observed In:	melanin biosynthetic process
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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