FIGURE

Fig. 6

ID

ZDB-FIG-260709-56

Publication

Valtorta et al., 2026 - Unprocessed U1 snRNAs as a biomarker of INTS11- and BRAT1-related neurodevelopmental disorders

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Analysis of BRAT1 and Integrator subunit protein levels in BRAT1-mutated patient-derived cells. A Immunoblot analysis of BRAT1, INTS11, INTS9, and INTS4 in fibroblasts and lymphoblastoid cell lines (LCLs) derived from the healthy control, unaffected parents and BRAT1-mutated patients. β-actin or α-tubulin was used as a loading control. A non-specific band is indicated by an asterisk (*). B Quantification of protein levels presented in (A) from at least three independent experiments. Data are shown as the mean ± SEM. Statistical significance was determined using a two-tailed Student’s t-test (ns – not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Genome Med.