FIGURE

Figure 4

ID

ZDB-FIG-260210-75

Publication

Wang et al., 2025 - Modeling epilepsy by loss-of-function of the CUG-binding protein Elav-like family member 2 in zebrafish with multi-omics analysis

Other Figures

All Figure Page

Back to All Figure Page

Figure 4

Single-cell transcriptomic analysis of celf2 mutant and WT embryos. (A) Single-cell transcriptomic analysis of WT and celf2^+/− embryos at 48 hpf was conducted. The bar chart illustrates the percentage of each cell type in celf2^+/− (blue) and WT embryos (red). (B) Cell types were annotated based on expressed marker genes and published datasets, and cells were visualized using UMAP. (C,D) The bubble plot depicts KEGG enrichment results for differentially expressed genes in GABAergic neurons and autonomic neuronal progenitor cell clusters. Each point’s size and color intensity represent gene count and adjusted P value. (E) UMAP plot after re-aggregating clustered cells. (F) KEGG enrichment results for both “MHBNeurGlutAll” (all glutamatergic neurons) and “MHBNeurGABAAll” (all GABAergic neurons) in this region, indicating differential changes in arginine and proline metabolism, as well as the GnRH signaling pathway. CELF2: CUGBP Elav-like family member 2; GnRH: Gonadotropin-releasing hormone; KEGG: Kyoto Encyclopedia of Genes and Genomes; UMAP: Uniform manifold approximation and projection; WT: Wild type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Chin. Med. J.