FIGURE

Fig. 4

ID

ZDB-FIG-260115-4

Publication

Monfrini et al., 2025 - RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Zebrafish treated with morpholino against rrp12 and noc3l. (A) Stage of development at day 7 after morpholino injection in the zebrafish embryos. Top and middle left: uninjected animals and embryos injected with control MO show normal development, normal head size, and straight body. Lower left: embryos injected with noc3l ATG MO also present normal development, size, and body strength. Right: embryos injected with rrp12 ATP MO presented different degrees of abnormalities on day 7, which were consistent with delayed development and significant reduction in head size (10% of embryos, top right), crimping, and developmental delay (77% of embryos, middle right), as well as severe crimping and developmental abnormalities (13% of embryos, lower right). (B) Survival was significantly reduced by day 6 in the rrp12-injected embryos, whereas it was only mildly reduced (to 80%) in noc3l ATG MO-injected fish. Control MO did not alter survival compared to uninjected animals.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-rrp12 WT + MO3-noc3l
Knockdown Reagents:	MO1-rrp12 MO3-noc3l
Observed In:	whole organism
Stage Range:	Long-pec to Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mov. Disord.