FIGURE

Figure 1

ID

ZDB-FIG-251127-51

Publication

Dominik et al., 2025 - Biallelic variants in ARHGAP19 cause a progressive inherited motor-predominant neuropathy

Other Figures

All Figure Page

Back to All Figure Page

Figure 1

Schematic representation of ARHGAP19 and genetic findings.

(A) Pathway showing GTPase-activating proteins (GAPs) such as ARHGAP19 responsible for promoting cycling of Rho GTPases between the active GTP-bound and the inactive GDP-bound conformations. GEF, Guanine nucleotide Exchange Factor; GDP, Guanine nucleotide diphosphate; GDI, Guanine Nucleotide Dissociation Inhibitor; Pi, dihydrogen phosphate. (B and C) Schematic diagrams of ARHGAP19 gene (B) and protein (C). Introns are not to scale. Exon numbers are according to the canonical transcript (NM_001136035). Amino acid changes are according to the reference sequence NP_001129507.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Journal of Clin. Invest.