FIGURE

FIGURE 6

ID

ZDB-FIG-251113-116

Publication

Ding et al., 2025 - An mTOR-Tfeb-Fabp7a Axis Ameliorates bag3 Cardiomyopathy via Decelerating Cardiac Aging

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FIGURE 6

Cardiomyocyte‐specific overexpression of fabp7a gene results in cardiac dysfunction. (A) Schematic constructs and design to generate a transgenic line with cardiomyocyte‐specific overexpression of fabp7a in zebrafish. (B, C) Cardiomyocyte‐specific overexpression of Fabp7a was indicated by fluorescence switch from mCherry to cerulean fluorescent protein (CFP) (B) and by Western blot analysis (C) at one week post‐4‐Hydroxytamoxifen (4‐HT) induction. (D, E) Cardiomyocyte‐specific overexpression of Fabp7a led to cardiac function decline (D) impaired sarcomere (arrows) and swollen mitochondria (asterisk) (E) at 3 months post‐4‐HT induction. (F) Quantitative RT‐PCR analysis of cardiomyopathy molecular markers in the cardiomyocyte‐specific overexpression of Fabp7a fish at 3 months post‐4‐HT induction. n = 3 biological replicates, one‐way ANOVA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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